Second-generation LAI are associated to favorable outcome in a cohort of incident patients diagnosed with schizophrenia

Investigate the associations of long-acting injectable (LAI) second generation antipsychotic drugs with number of relapses, psychiatric admissions, days hospitalized, intentional self-harm events, and costs linked to hospitalizations in incident patients diagnosed with schizophrenia.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research

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CONCLUSIONS: Our data indicate that compared with the FESZ patients, brain GMV aberrances was increased in the CSZ patients. The functional features including DC, ReHo, and ALFF, could facilitate FESZ diagnosis, which is more sensitive than structural features in classification. The SVM with RFE presents excellent classification performance and assists SZ diagnosis. PMID: 30338811 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Castelon Konkiewitz E, Ziff EB Abstract In this essay, we propose an association between Franz Kafka's novel, The Trial, and phenomenological and neurobiological processes in schizophrenia. We begin by presenting a summary of the plot, pointing to some of its remarkable literary aspects. We next compare the mental processes of dissociation, disorientation and delusion as represented in the novel with phenomenological processes that take place in the prodromal states of schizophrenia. We discuss how such disorders of the self and disorders of thought, both crucial aspects of the schizophrenic experience, ap...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
Renaming schizophrenia: 5 × 5. Epidemiol Psychiatr Sci. 2018 Oct 18;:1-4 Authors: Guloksuz S, van Os J Abstract There had been a long way to go before we felt comfortable about even discussing the issues revolving around the concept of 'schizophrenia', let alone reckoning on mere semantic revision. In this editorial, we aim to extend our discussion on the reasons behind the slow death of the concept of 'schizophrenia' and the benefits of changing the name and embracing a spectrum approach with an umbrella psychosis spectrum disorder (PSD) category (similar to autism spectrum disorder) that goes f...
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
Sustained-Release Risperidone via Subcutaneous Injection: A Systematic Review of RBP-7000 (PERSERIS™) for the Treatment of Schizophrenia. Clin Schizophr Relat Psychoses. 2018;12(3):130-141 Authors: Citrome L Abstract RBP-7000 (PERSERIS™) is a once-monthly subcutaneously administered formulation of risperidone that does not require oral supplementation when initiated. As with risperidone microspheres, RBP-7000 is required to be stored in a refrigerator. The injection kit, consisting of two syringes (one containing liquid polymer, the other containing risperidone powder), will need to come to...
Source: Clinical Schizophrenia and Related Psychoses - Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research
Authors: Buckley PF PMID: 30339051 [PubMed - in process]
Source: Clinical Schizophrenia and Related Psychoses - Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research
In this study, we showed that the Val allele at Val158Met (rs4680) may be associated with the homicidal behavior of schizophrenia patients as well as that the methylation level of Val158Met (rs4680) could be affected by the variation of Val158Met (rs4680) and eventually contribute to the violent behavior of schizophrenia patients.
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
Immunological pathways play a crucial role in developing and precipitating neuropsychiatric disorders. Although the exact pathogenesis of schizophrenia is unknown, the possible role of genetic and biomarker involvement of the immune system is gaining attention. Here we quantified the mRNA expression of cytokines as a key role player of the immune system from the peripheral blood mononuclear cells of patients with schizophrenia and healthy controls to identify the differentially expressed genes.
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research
AbstractIndividuals with disorders that include psychotic symptoms (i.e. psychotic disorders) experience broad cognitive impairments in the chronic state, indicating a dimension of abnormality associated with the experience of psychosis. These impairments negatively impact functional outcome, contributing to the disabling nature of schizophrenia, bipolar disorder, and psychotic depression. The robust and reliable nature of cognitive deficits has led researchers to explore the timing and profile of impairments, as this may elucidate different neurodevelopmental patterns in individuals who experience psychosis. Here, we revi...
Source: Neuropsychology Review - Category: Neuroscience Source Type: research
Date: Wednesday, 11 14, 2018; Speaker: Carol Tamminga, MD, Lou and Ellen McGinley Distinguished Chair , the McKenzie Chair in Psychiatry and Chairman, Department of Psychiatry , Department of Psychiatry, University of Texas Southwestern Med School; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
When I was first reading up on JM (identifying information changed), I thought the case would go smoothly, well, as smoothly as any inpatient psychiatry case can go. All I had known about her is that she was an elderly woman who was recently released from jail. When the staff came to escort JM to her freedom, instead of being overjoyed as most likely would be, she was agitated and said she would not speak with them and would not leave until she was ready. She was also speaking to someone else in the cell that the staff could not see or hear. The staff came to find out that she was speaking to Jesus Christ regarding an ongo...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Education Psychiatry Source Type: blogs
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