Multiparametric radiomics improve prediction of lymph node metastasis of rectal cancer compared with conventional radiomics

Publication date: Available online 7 July 2018Source: Life SciencesAuthor(s): Li-Da Chen, Jin-Yu Liang, Hui Wu, Zhu Wang, Shu-Rong Li, Wei Li, Xin-Hua Zhang, Jian-Hui Chen, Jin-Ning Ye, Xin Li, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Jian-Bo Xu, Wei WangAbstractAimsTo establish multiparametric radiomics of rectal tumor for the preoperative prediction of lymph node (LN) metastasis.Materials and methodsThis prospective study consisted of 115 consecutive patients with rectal carcinoma between April 2015 and April 2017. The multiparametric radiomics scores were extracted from the endorectal ultrasound (ERUS), computed tomography (CT) and shear-wave elastography (SWE) features of the rectal tumor, LN, and peripheral tissues. The three radiomics scores were generated. Further validation as an independent predictor was performed using multivariate logistic regression together with clinical data, and a nomogram was subsequently developed. The predictive performance of the multiparametric radiomics nomogram was compared with that of conventional radiomics.Key findingsAll three scores (ERUS, CT, and SWE) were significantly higher in patients with LN metastasis than in patients with negative LN metastasis (all P < 0.05) in both training and validation set. Multivariate analysis indicated that CT and SWE scores were independent risk variables (odds ratio, OR = 6.764 and 5.482, respectively). In validation cohort, the multiparametric radiomics nomogram showed the highest predict...
Source: Life Sciences - Category: Biology Source Type: research