Epigenetics and its implications for oral health

ConclusionEpigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research

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Publication date: Available online 15 July 2019Source: European Journal of RadiologyAuthor(s): Felix Feldhaus, Georg Böning, Martin Jonczyk, Johannes Kahn, Uli Fehrenbach, M. Maurer, D. Renz, Bernd Hamm, Florian StreitparthAbstractPurposeWe determined whether the Smart MAR metal artifact reduction tool - a three-stage, projection-based, post processing algorithm - improves subjective and objective image quality and diagnostic confidence in patients with dental artifacts and suspected head and neck pathology compared to standard adaptive statistical iterative reconstructions (ASIR V) alone.MethodThe study included 100 ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 15 July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Reyna Aguilar Quispe, Ana Carolina Cunha Rodrigues, Ana Maria Greff Buaes, Ana Lucia Alvares Capelozza, Cássia Maria Fischer Rubira, Paulo Sérgio da Silva SantosAbstractObjectiveTo evaluate dental abnormalities and dental maturity in permanent dentition of childhood cancer survivors (CCS) and to compare them with healthy individuals.Study designA retrospective, case-control study, with convenience sampling, evaluated 111 panoramic radiographs (PR) of CCS compared to 111 PR of healthy...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusions: A simple, convenient, accurate, and robust 2-dimensional liquid chromatography method was developed and verified, which successfully determined the plasma concentrations of apatinib in patients with gastric cancer.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
AbstractApoptosis, the process of programmed cell death, occurs normally during development and aging. Members of the B-cell lymphoma 2 (BCL2) family of proteins are central regulators of apoptosis, and resistance to apoptosis is one of the hallmarks of cancer. Targeting the apoptotic pathway via BCL2 inhibitors has been considered a promising treatment strategy in the past decade. Initial efforts with small molecule BH3 mimetics such as ABT-737 and ABT-263 (navitoclax) pioneered the development of the first-in-class Food and Drug Administration (FDA)-approved oral BCL2 inhibitor, venetoclax. Venetoclax was approved for th...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionVinorelbine pharmacokinetics were found to be comparable between Asian and European patients. No relevant influence of ethnicity on vinorelbine bioavailability and clearance for oral and intravenous routes of administration was observed.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionsThe CNS penetration observed was encouraging enough to move ribociclib forward with preclinical efficacy studies in models of pediatric brain tumors.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.
Source: The Scientist - Category: Science Tags: Notebook Magazine Issue Source Type: news
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very at...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
To evaluate dental abnormalities and dental maturity in permanent dentition of childhood cancer survivors (CCS) and to compare them with healthy individuals.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Research Article Source Type: research
AbstractPositron emission tomography/computed tomography (PET/CT) is a standard procedure for imaging cancer commonly used in the clinical practice for several diseases, in particular for cancer staging, restaging, treatment monitoring and radiation therapy planning. Despite the availability of many radiotracers, 18F-fluoro-2-deoxy-2-d-glucose ([18F]FDG) is the most used. International PET/CT guidelines propose protocols for patients ’ correct preparation before [18F]FDG injection, in particular with the regard of diabetic patients and therapy management. Hyperglycemic conditions and oral or insulin medication showed...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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