Sex-specific expression of apolipoprotein levels following replenishment of vitamin D

Publication date: June 2018Source: The Journal of Steroid Biochemistry and Molecular Biology, Volume 180Author(s): Nasser M. Al-Daghri, Kaiser Wani, Shaun Sabico, Spiro D. Garbis, George P. Chrousos, Osama E. Amer, Mohammed Ghouse Ahmed Ansari, Yousef Al-Saleh, Naji J. Aljohani, Omar S. Al-Attas, Majed S. AlokailAbstractNumerous studies have been done to establish the relationship between vitamin D and lipids, yet a definitive causal link is not found. This interventional study aims to evaluate and compare levels of apolipoproteins among vitamin D deficient subjects at baseline and after they achieved full vitamin D status correction.120 Saudi adults with vitamin D deficiency [25(OH)D < 50nmol/l] were recruited and given 50,000IU cholecalciferol weekly for first 2 months, then twice a month for next 2 months, followed by daily 1000IU until month 6. Blood samples were taken at baseline and after 6 months. Serum 25(OH)D, lipid profile and apolipoproteins (A1, A2, B, C1, C2, C3, E and H) were analyzed using commercially available kits. Overall, serum 25(OH)D increased significantly(63.3 ± 16.5nmol/l at end of study vs. 32.5 ± 10.8 at baseline; p < 0.0001). In parallel, a significant increase in apolipoproteins C1, C2, C3 and E (all p-values < 0.01) and a significant decrease in apolipoprotein B (p = 0.02) was observed. Following, stratification according to sex, apolipoproteins C2 and C3 significantly increased only in males (p-values <...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research