Clinical and demographic features of chronic progressive external ophthalmoplegia in a large adult-onset cohort

Publication date: Available online 12 December 2017Source: MitochondrionAuthor(s): Julia N. Heighton, Lauren I. Brady, Matthew C. Newman, Mark A. TarnopolskyAbstractChronic progressive external ophthalmoplegia (CPEO) is a common mitochondrial disease. We evaluated the impact of sex and smoking status upon knee extension strength and the phenotypic spectrum of disease in a large cohort of adult-onset CPEO patients (N = 116) using retrospective chart analysis. The CPEO patients showed significantly lower knee extension strength as compared to the age- and sex-matched control population (− 37%, P < 0.05). Smoking also negatively impacted knee extension strength only in women with CPEO (− 26%, P < 0.05). We conclude that smoking and female sex interact negatively in CPEO patients.
Source: Mitochondrion - Category: Biochemistry Source Type: research