Recent advances in modulator technology for comprehensive two dimensional gas chromatography

Publication date: Available online 5 May 2018Source: TrAC Trends in Analytical ChemistryAuthor(s): H. Daniel Bahaghighat, Chris E. Freye, Robert E. SynovecAbstractOne of the greatest advancements in the field of gas chromatography (GC) has been the development of comprehensive two-dimensional gas chromatography (GC × GC). As the field of GC evolved from one-dimensional gas chromatography (1D-GC) to heart cutting (GC–GC), followed by the advent of GC × GC, the critical component at the center of this evolution has been the interface between the separation columns. The interface, referred to as the modulator for GC × GC, links the primary and secondary columns. This review covers the evolution of modulator systems from the founding of GC × GC in 1991 by Liu and Phillips, while focusing on the last six years. Since its inception, modulators have evolved into two distinct categories: thermal, and valve-based. The advantages and shortcomings of each category will be covered. Recent developments in the research, development, and commercialization of these various modulators is provided, with a glimpse into future modulator designs.

Source: TrAC Trends in Analytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research