Biodegradable PHBH/PVA blend nanofibers: Fabrication, characterization, in vitro degradation, and in vitro biocompatibility

Publication date: August 2018Source: Polymer Degradation and Stability, Volume 154Author(s): Rina Afiani Rebia, Sélène Rozet, Yasushi Tamada, Toshihisa TanakaAbstractElectrospinning was used to fabricate the different ratio of poly [(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] (PHBH)/Poly (vinyl alcohol) (PVA) blend nanofibers. These nanofibers of ratio PHBH/PVA 100/0, 90/10, 70/30, and 50/50 were prepared by using HFIP as solvent. Mixed solvent of HFIP/water was used to prepare for PHBH/PVA 30/70, 10/90 and water was used for pure PVA. The characteristic of morphology, thermal properties, miscibility, wettability, water absorption, and enzymatic biodegradable behaviour of these blend nanofibers have been investigated. The result indicated that PHBH/PVA blend nanofibers are immiscibility in the crystalline phase from DSC analysis with two peaks appear in 137 °C and 230 °C in the blend nanofibers. WAXD pattern of the blend nanofiber also exhibited the decrease of PHBH crystalline intensity with the increase of PVA content. However, FTIR spectra of blend nanofiber displayed the shift of hydroxyl and carbonyl stretching band which indicates the intermolecular interaction in amorphous phase. The water contact angle values increased with the increase of PVA content more than 30%. These showed the surface of blend nanofibers were hydrophobic since WCA value was more than 90°. The increase of WCA value is due to surface morphological change that is the decrease of fiber...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research