Anti-inflammatory lignans from Melodinus suaveolens

Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): Lei Fang, Zhong-Ying Fang, Peng Zhou, Jie Bao, Jin-Hai Yu, Jin-Tong Song, Jie Zhou, Hua ZhangAbstractThree new lignans, melodinins A–C (1–3), together with four known analogues (4–7), were isolated from the stems of Melodinus suaveolens. Their structures including relative configurations were determined by spectroscopic methods, including 1D and 2D NMR, and HRESIMS. Their absolute configurations were unambiguously assigned by electronic circular dichroism (ECD) experiments, especially the application of ECD exciton chirality method. Anti-inflammatory evaluation revealed that compounds 1, 2, 4, and 5 exhibited moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor, with IC50 values ranging from 1.68 to 9.56 μM.Graphical abstract

Source: Phytochemistry Letters - July 11, 2018 Category: Chemistry Source Type: research