Diels–Alder type adducts with potent alpha-glucosidase inhibitory activity from Morus macroura

Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): Yi-Fan Wang, Mei-Hua Yu, Liang-Jin Xu, Li-Xin Niu, Chun-Yue Huang, Hui Xu, Pei-Ming Yang, Xiao HuAbstractTwo new Diels–Alder type adducts, macrourins I and J (1–2), along with seven known analogues (3–9) were isolated from the stems of Morus macroura Miq. The structures of the two new compounds were elucidated by extensive analysis of spectroscopic data. Compounds 1–9 all showed highly potent in vitro α-glucosidase inhibitory activities, and the IC50 values of compounds 1 and 2 were 1.70 and 1.58 μM, respectively, approximately 800 times stronger than the positive control, acarbose.Graphical abstract

Source: Phytochemistry Letters - July 11, 2018 Category: Chemistry Source Type: research