Synthesis, characterization and antibacterial studies of schiff based 1,2,3-triazole bridged silatranes

Publication date: 15 September 2018Source: Journal of Organometallic Chemistry, Volume 871Author(s): Gurjaspreet Singh, Jasbhinder Singh, Akshpreet Singh, Jandeep Singh, Manoj Kumar, Kshitiz Gupta, Sanjay ChhibberAbstractA single step Cu (I) assisted click silylation reaction had been used for the synthesis of novel Schiff based 1,2,3-triazole bridged silatrane (SBTBS)-scaffolds (5a-5f) using polyfunctionalised Schiff based 1,2,3-triazole bridged organotriethoxysilanes (SBTBOTS) (4a-4f) as precursors. These compounds were synthesized in excellent yields using an economical, simple and biocompatible synthetic procedure and their structures were characterized by various spectroscopy methods such as IR, NMR (1H and 13C) and elemental analysis. The presence of different pharmacologically active segments into a single triazole unit can result into impressive achievement in their bioactivity. So, antibacterial studies of the silatranes (5a-5f) were also carried out and it was observed that all the compounds showed potential antibacterial activity. The results also indicate that activity of compound 5f is even comparable to the standard drug, cefepime.Graphical abstract

Source: Journal of Organometallic Chemistry - July 11, 2018 Category: Chemistry Source Type: research