Organosilicon based synthesis of new functionalized aminomethylenediphosphonates with moieties of amino acids

Publication date: 15 September 2018Source: Journal of Organometallic Chemistry, Volume 871Author(s): Andrey A. Prishchenko, Roman S. Alekseyev, Mikhail V. Livantsov, Olga P. Novikova, Ludmila I. Livantsova, Valery S. PetrosyanAbstractThe new functionalized aminomethylenediphosphonates with moieties of various amino acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of aminomethylenediphosphonates with the methanol excess resulted in the water-soluble functionalized aminomethylenediphosphonic acids.Graphical abstract

Source: Journal of Organometallic Chemistry - July 11, 2018 Category: Chemistry Source Type: research