Encapsulation of camptothecin into pegylated polyelectrolyte nanocarriers

In this study, pegylated polyelectrolyte nanocapsules were utilized to prepare camptothecin nanocarriers. Nanosize droplets containing the camptothecin were encapsulated in polyelectrolyte multilayer shells formed by sequential adsorption of polyelectrolytes technique. The nanocapsules were pegylated for passive targeting through the adsorption of the pegylated polyelectrolyte. The biological effects of encapsulated camptothecin on two tumor cell lines: mouse colon carcinoma cell line CT26-CEA and the mouse mammary carcinoma cell line 4T1 were studied. Obtained results suggest, that encapsulated drug, as well as free one, showed similar activity on the tested cells.Graphical abstract
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research