Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke

Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed KhalifaAbstractWaterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. The amiodarone gavage significantly increased serotonin content in brainstem and cerebral cortex after 8 and 2 weeks respectively and dopamine content at most of time intervals. Moreover, waterpipe smoke exposure induced a significant decrease in dopamine content after 2 weeks in brainstem and in serotonin content after 4, 6 weeks in brainstem and 6, 8 weeks in cerebral cortex. While, increment in dopamine content after 4, 6 weeks in brainstem and 6, 8 weeks in cerebral cortex may be due to increase its synthesis which strengthens the coughing reflex. Amiodarone gavage and waterpipe smoke exposure induced a significant increase in myeloperoxidase activity, hydroxyproline content and nitric oxide level in lung; while, catalase activity was decreased significantly. Consequently, waterpipe smoke exposure for long time caused serious harmful effects on br...
Source: Egyptian Journal of Basic and Applied Sciences - Category: Science Source Type: research