Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?

Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore long-term ovarian endocrine function that can persist for more than 7 years (12 years if the procedure is repeated). If ovarian tissue reimplantation is capable of restoring ovarian activity after menopause induced by chemotherapy, radiotherapy, surgery, or a combination of all three, why not propose it to recover sex steroid secretion after natural menopause and prevent menopause-related conditions in the ageing population? In this application, the graft site could be outside the pelvic cavity, e.g., forearm or rectus muscle. Could ovarian tissue freezing at a young age followed by reimplantation upon reaching menopause be the anti-ageing therapy of the future? Sufficient existing evidence now surely merits serious debate.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Publication date: Available online 19 January 2019Source: Nitric OxideAuthor(s): Danielle Jin-Kwang Kim, Carly A. Roe, Yasina Somani, David J. Moore, Megan A. Barrett, Michael Flanagan, Daniel B. Kim-Shapiro, Swati Basu, Matthew D. Muller, David N. ProctorAbstractPurposeConsumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated in...
Source: Nitric Oxide - Category: Chemistry Source Type: research
DR MICHAEL MOSLEY: Do men experience a similar condition to menopause in mid-life?
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Link between mindfulness and symptoms more robust in women experiencing higher stress
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Gynecology, Psychiatry, Journal, Source Type: news
AbstractBackgroundBariatric surgery is associated with a reduced risk of developing certain malignancies, particularly in women. However, the impact of bariatric surgery on tumor characteristics, cancer treatment, and oncologic outcomes is unknown.MethodIn a retrospective cohort study, 42 subjects diagnosed with breast cancer after bariatric surgery (1989 –2014) were matched to 84 subjects with breast cancer (1984–2012) who did not undergo bariatric surgery, based on age, body mass index (BMI), and menopausal status at the time of breast cancer diagnosis, as well as the date of cancer diagnosis. Medical records...
Source: Obesity Surgery - Category: Surgery Source Type: research
(Reuters Health) - Women going through menopause may have fewer symptoms of depression when they get treatment for insomnia than when they don't, a recent experiment suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
FRIDAY, Jan. 18, 2019 -- Higher mindfulness and lower stress are independently associated with lower menopausal symptom scores among midlife women, according to a study published online Jan. 17 in Climacteric. Richa Sood, M.D., from the Mayo Clinic...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionYounger initiation of HRT may be effective in reducing death and cardiac events. However, younger HRT initiators remained at an increased risk of stroke, TIA and systemic embolism and this risk increased as average age increased. Younger menopausal women using HRT to treat vasomotor symptoms do not appear to be at an increased risk of dying or experiencing CHD events.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Authors: Osuga Y, Torng PL, Jeng CJ Abstract We aimed to examine how leuprorelin has been studied for the treatment of women with endometriosis in Asia. We conducted a literature search of PubMed, the Cochrane Library and ClinicalTrials.gov. This review includes randomised trials of women with endometriosis treated with leuprorelin in Asia. Phase I-IV clinical trials published between January 1 2000 and December 31 2016 and written in English were included. Four studies were identified, showing that leuprorelin significantly improves pain and quality of life. The oestrone and oestradiol levels are decreased by leup...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Bleeding after menopause can be disconcerting, but the good news is, more than 90% of the time it’s not caused by a serious condition, according to a study in JAMA Internal Medicine. That said, the study also reinforces the idea that postmenopausal bleeding should always be checked out by your doctor to rule out endometrial cancer, a cancer of the uterine lining, says Dr. Ross Berkowitz, William H. Baker Professor of Gynecology at Harvard Medical School. This is because the study also found more than 90% of women who did have endometrial cancer had experienced postmenopausal bleeding. And screening all women who...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
UCLA and UC San Francisco life scientists have discovered a dramatic pattern of bone growth in female mice — research that could potentially lead to stronger bone density in women and new treatments for osteoporosis in older women.The researchers found that blocking a particular set of signals from a small number of neurons in the brain causes female, but not male, mice to build super-strong bones and maintain them into old age. These neurons may play an important role in controlling women ’s bone density, the researchers said. Thestudy was published Jan. 11 in the journal  Nature Communications.“We ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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