Long-Distance Relationships: Suppression of Repeat-Mediated Deletions

Publication date: Available online 24 May 2018Source: Trends in GeneticsAuthor(s): Maria E. Morales, Tiffany Kaul, Prescott DeiningerThe high proportion of repetitive DNA sequences in the human genome provides tremendous opportunities for DNA rearrangements between non-allelic repetitive elements. The genome must use multiple competing and collaborating repair mechanisms to minimize these types of DNA rearrangements, some of which fail in cancer cells where DNA repair pathways are suppressed.
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research