Genetic-Driven Druggable Target Identification and Validation

Publication date: July 2018Source: Trends in Genetics, Volume 34, Issue 7Author(s): Matteo Floris, Stefania Olla, David Schlessinger, Francesco CuccaChoosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here, we discuss opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline.

Source: Trends in Genetics - July 10, 2018 Category: Genetics & Stem Cells Source Type: research