Subtractive proteomics revealed plausible drug candidates in the proteome of multi-drug resistant Corynebacterium diphtheriae

Publication date: September 2018Source: Meta Gene, Volume 17Author(s): Zunera Khalid, Sajjad Ahmad, Saad Raza, Syed Sikander AzamAbstractMulti-drug resistant Corynebacterium diphtheriae, an etiological agent of diphtheria, is a major health concern because of its resistance to major clinically used antibiotics. The said pathogen is highly resistant to lincosamides, macrolides, streptogramin, tetracycline, trimethoprim, chloramphenicol and benzylpenicillin and as such, required an urgent need of novel drug targets identification. Here, in this present study, we employed an in silico based approach for identifying potential drug candidates in C. diphtheriae NCTC 13129 proteome. In a sequential filtration approach, we identified three host non-homologous, essential, unique, cytoplasmic, virulent, resistant, physicochemically suitable, and druggable proteins. These proteins: MtrA, MprA and RegX3 are members of C. diphtheriae OmpR/PhoB system and are potential drug targets that will presumably accelerate novel drug discovery for the pathogen.Graphical abstract
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research