Surgical Treatment for Esophageal Cancer: Are the Questions Finished or Are the Surgeons Finished by the Questions?

Publication date: April 2018Source: Cirugía Española (English Edition), Volume 96, Issue 4Author(s): David Ruiz de Angulo, Pascual Parrilla
Source: Cirugia Espanola - Category: Surgery Source Type: research

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Authors: Bertolini M, Dongari-Bagtzoglou A Abstract Candida albicans is an opportunistic pathogen colonizing the oropharyngeal, esophageal, and gastrointestinal mucosa in most healthy humans. In immunocompromised hosts, this fungal organism can cause mucosal candidiasis in these sites. C. albicans also causes fungemia, a serious consequence of cancer cytotoxic chemotherapy, which is thought to develop from fungal translocation through compromised mucosal barriers. Changes in endogenous bacterial population size or composition as well as changes in the host environment can transform fungal commensals into opportunis...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Cell Death &Disease, Published online: 18 November 2019; doi:10.1038/s41419-019-2114-zHIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
AbstractPurpose of reviewWith a globally aging population, dysphagia is a growing health concern among elderly. Increasing reflux disease has contributed to an increased prevalence of dysphagia from peptic strictures and esophageal cancer. Dysphagia can lead to malnutrition and aspiration pneumonia, causing considerable morbidity and mortality. This review article focuses on recent advances in the approach and management of esophageal dysphagia.Recent findingsEndoscopic functional luminal imaging probe is a novel test that complements upper endoscopy, esophagram, and esophageal manometry for evaluation of esophageal dyspha...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Condition:   Patients With Esophageal Cancer(Ⅱ-Ⅲ) Interventions:   Drug: endostar+chemoradiotherapy;   Other: chemoradiotherapy Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We conducted risk analyses using the competing risk regression model, which defined death and the development of second malignancies as competing risks. Our study revealed that risk of second primary malignancies was significantly higher compared with the general population. Age, clinical stage, and tumor location were identified as significant factors for the development of second primary malignancies. AbstractBackgroundEsophageal cancer is associated with synchronous or metachronous cancer at other primary sites. However, few studies have evaluated the second malignancies after the treatment of esophageal cancer. The pre...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
MicroRNA-1275 induces radiosensitization in oesophageal cancer by regulating epithelial-to-mesenchymal transition via Wnt/β-catenin pathway. J Cell Mol Med. 2019 Nov 15;: Authors: Xie C, Wu Y, Fei Z, Fang Y, Xiao S, Su H Abstract Acquired radioresistance is one of the main obstacles for the anti-tumour efficacy of radiotherapy in oesophageal cancer (EC). Recent studies have proposed microRNAs (miRNAs) as important participators in the development of radioresistance in various cancers. Here, we investigated the role of miR-1275 in acquired radioresistance and epithelial-mesenchymal transition (EMT...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis of human cancers. However, the role of circRNAs in esophageal squamous cell carcinoma (ESCC) re...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
nimo Isabel Bravo Esophageal cancer (EC) is the seventh most common cancer worldwide and the sixth leading cause of death, according to Globocan 2018. Despite efforts made for therapeutic advances, EC remains highly lethal, portending a five-year overall survival of just 15–20%. Hence, the discovery of new molecular targets that might improve therapeutic efficacy is urgently needed. Due to high proliferative rates and also the limited oxygen and nutrient diffusion in tumors, the development of hypoxic regions and consequent activation of hypoxia-inducible factors (HIFs) are a common characteristic of solid ...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
k The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias—normal tissue arising in an abnormal location—and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett’s esophagus) a...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
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