Diagnostic and prognostic tests in systemic lupus erythematosus

Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Natalia Vasquez-Canizares, Dawn Wahezi, Chaim PuttermanAbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better understanding of the etiopathogenesis of complex diseases, including SLE. Here we present a review of the latest advancements in biomarker discovery during the “omics” era, using these novel technologies, for assisting in the diagnosis and prognosis of patients with SLE.
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research