Understanding the role of environmental factors in the development of systemic lupus erythematosus

Publication date: June 2017Source: Best Practice &Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use. Emerging research results suggest possible associations of SLE risk with exposure to solvents, residential and agricultural pesticides, heavy metals, and air pollution. Ultraviolet light, certain infections, and vaccinations have also been hypothesized to be related to SLE risk. Mechanisms linking environmental exposures and SLE include epigenetic modifications resulting from exposures, increased oxidative stress, systemic inflammation and inflammatory cytokine upregulation, and hormonal effects. Research needs to include new studies of environmental risk factors for SLE in general, with a focus on lifetime exposure assessment. In ad...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research

Related Links:

Purpose of review The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics. Recent findings Smoking is associated with an increased risk for most of the autoimmune diseases. Carbamylation of proteins as well as NETosis have emerged as possible new pathop...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: INFECTIONS AND ENVIRONMENTAL ASPECTS OF AUTOIMMUNITY: Edited by Yehuda Shoenfeld Source Type: research
Publication date: Available online 21 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. Costenbader Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for i...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
BY UWE REINHARDT In tribute to Uwe we are re-running this instant classic from THCB’s archives. Originally published on Jan 31, 2017. Everyone knows (or should know) that forcing a commercial health insurer to write for an individual a health insurance policy at a premium that falls short of the insurer’s best ex ante estimate of the cost of health care that individual will require is to force that insurer into what economists might call an unnatural act. Remarkably, countries that rely on competing private health insurers to operate their universal, national health insurance systems all do just that. They a...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Repeal Replace Trending Uwe Reinhardt Source Type: blogs
AbstractVitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this categ...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Before the medical community had better understanding of the mechanisms that cause disease, doctors believed certain ailments could originate from imbalances in the stomach. This was called hypochondriasis. (In Ancient Greek, hypochondrium refers to the upper part of the abdomen, the region between the breastbone and the navel.) This concept was rejected as science evolved and, for example, we could look under a microscope and see bacteria, parasites, and viruses. The meaning of the term changed, and for many years doctors used the word “hypochondriac” to describe a person who has a persistent, often inexplicab...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Source Type: blogs
Immusorba TR (IM-TR) and PH (IM-PH) were developed as immunoadsorbents from nonbiological materials as affinity ligands for removal of pathogenic substances. The immunoadsorbents in IM-TR and IM-PH are immobilized on a polyvinyl alcohol gel with tryptophan and phenylalanine, respectively, as a ligand. IM-TR is mainly clinically applied to autoimmune neurological diseases such as myasthenia gravis, Guillain-Barr é syndrome, and multiple sclerosis. IM-PH is also applied to neurological diseases but mainly to rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Review Source Type: research
Conclusions: Our results provide novel evidence of associations between exposure to some pesticides and RA in male farmers. https://doi.org/10.1289/EHP1013 Received: 24 August 2016 Revised: 19 January 2017 Accepted: 13 February 2017 Published: 14 July 2017 Address correspondence to C.G. Parks, Epidemiology Branch, A3-05, National Institite of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27599 USA; Telephone: (919) 541-2577; Email: Parks1@mail.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1013). The authors declare that they have...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use.
Source: Best Practice and Research. Clinical Rheumatology - Category: Rheumatology Authors: Tags: 2 Source Type: research
BY UWE REINHARDT Everyone knows (or should know) that forcing a commercial health insurer to write for an individual a health insurance policy at a premium that falls short of the insurer’s best ex ante estimate of the cost of health care that individual will require is to force that insurer into what economists might call an unnatural act. Remarkably, countries that rely on competing private health insurers to operate their universal, national health insurance systems all do just that. They allow each insurer to set the premium for a government-mandated , comprehensive benefit package, but require that each insurer...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Uwe Reinhardt Source Type: blogs
Selena Gomez announced Tuesday in a statement that she is taking time off to focus on her “health and happiness.”  “As many of you know, around a year ago I revealed that I have lupus, an illness that can affect people in different ways,” Gomez told People exclusively. “I’ve discovered that anxiety, panic attacks and depression can be side effects of lupus, which can present their own challenges.” The “Hands to Myself” singer revealed her diagnosis last October after about two years of speculation that the 24-year-old was suffering from lupus. Gomez told Billb...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
More News: Alcoholism | Autoimmune Disease | Environmental Health | Epidemiology | Genetics | Hormone Replacement Therapy | Hormones | Lupus | Rheumatology | Smokers | Study | Vaccines | Women