Metabonomic profiling of chronic intermittent hypoxia in a mouse model

In this study, the urinary metabonomic profile associated to intermittent hypoxia was evaluated in a mouse model.When exposed to intermittent hypoxia, animals showed a significant alteration in energy metabolism towards anaerobic pathways and signs of OS imbalance. A compensatory response was observed over time. Our data also indicates an excess production of vitamin B3, liver function modulations and a stimulation of creatine synthesis which could be used to evaluate the ChIH repercussions. As well, TMAO and allantoin could constitute interesting biomarker candidates, respectively in the context of cardiovascular risk and OS associated to OSA.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research