The pharmacological treatment of chronic comorbidities in COPD: mind the gap!

Conclusionsa truly comprehensive view of the complex COPD patient, hopefully capitalizing on multidimensional geriatric assessment, is needed to dissect the many components of health status impairment and to provide the optimal care. Selected screening procedures are highly desirable to identify frequently missed comorbidities. Pharmacosurveillance is an essential part of the approach to COPD and its comorbidities.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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CONCLUSION: The results suggest that these changes may contribute to the mechanotransduction disturbance evidenced in chagasic cardiomyopathy. PMID: 31433004 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Conclusion: This review suggests patients with RVO have an increased risk of cardiovascular events and all-cause mortality. More studies are needed to determine the highest risk periods for cardiovascular events and mortality after RVO and whether immediate cardiovascular evaluation and intervention will improve outcomes.
Source: RETINA - Category: Opthalmology Tags: Review Source Type: research
Abstract Methadone poisoning has become more common in the pediatric population due to extensive use of methadone maintenance therapy (MMT). It is associated with decreased level of consciousness, coma, respiratory distress and cardiac intoxication. The cardiac complications have been reported to be QT prolongation, torsade de pointes, coronary artery disease, arrhythmia, stress cardiomyopathy and death. We herein report two pediatric patients with accidental methadone poisoning who developed stress cardiomyopathy and cardiac failure. The first case was a 4-yaer-old girl and the second one was an 18-month-old girl...
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Abhinav Sharma, Justin A. Ezekowitz
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Paolo RaggiAbstractIf a disease state is highly prevalent and its consequences are severe, it may be appropriate to seek methods to identify it early in order to forestall its development and complications. Diabetes mellitus is a proven risk factor for the development of atherosclerosis although its face and outcome are changing as shown in contemporary clinical trials. In fact, decompensated heart failure (HF) seems to drive the hospitalization rate in patients with diabetes and the mortality from HF is reduced with modern hypo...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionSZYQD may regulate the Cholinergic synapse, Th17 cell differentiation, Fluid shear stress and atherosclerosis, Apoptosis, PI3K-Akt signaling pathway, NF-κB signaling pathway, TNF signaling pathway, C-type lectin receptor signaling pathway and so on, to resist oxidation, diminish inflammation, balance proliferation and apoptosis of cells, inhibit vagal excitation in the treatment of COPD.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 23 August 2019Source: Journal of Cardiology CasesAuthor(s): Vincenzo De Simone, Paola Guarise, Gabriele Zanotto, Giorgio MorandoAbstractPulmonary hypertension due to left heart disease (PH-LHD) frequently complicates heart failure with reduced ejection fraction (HFrEF). Specific therapies for PH have not offered an advantage in patients with PH-LHD. The combined angiotensin receptor blocker–neprilysin inhibitor (ARNI), sacubitril/valsartan, is a novel therapy that can increase levels of natriuretic peptides (NPs). The resulting action on natriuresis and vasodilation may play an impo...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: September 2019Source: Global Heart, Volume 14, Issue 3Author(s): João Pedro Ferreira, Sarah Kraus, Sharon Mitchell, Pablo Perel, Daniel Piñeiro, Ovidiu Chioncel, Roberto Colque, Rudolf de Boer, Juan Esteban Gomez-Mesa, Hugo Grancelli, Carolyn S.P. Lam, Antoni Martinez-Rubio, John J.V. McMurray, Alexandre Mebazaa, Gurusher Panjrath, Ileana L. Piña, Mahmoud Sani, David Sim, Mary Walsh, Clyde Yancy
Source: Global Heart - Category: Cardiology Source Type: research
Authors: Gong DJ, Wang L, Yang YY, Zhang JJ, Liu XH Abstract Diabetic patients are more susceptible to renal ischemia/reperfusion (I/R) injury (RI/RI) and have a poor prognosis, but the underlying mechanism remains unclear. The present study aimed to examine whether diabetes could worsen acute kidney injury induced by I/R in rats and clarify its mechanism. Control and streptozotocin-induced diabetic rats were subjected to 45 min renal pedicle occlusion followed by 24 h reperfusion. Tert-butylhydroquinone (TBHQ, 16.7 mg/kg) was administrated intraperitoneally 3 times at intervals of 8 h b...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLES Source Type: research
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