Understanding the pathophysiology of hyperglycemia-associated chorea-ballism: a systematic review of positron emission tomography findings.

Understanding the pathophysiology of hyperglycemia-associated chorea-ballism: a systematic review of positron emission tomography findings. Funct Neurol. 2018 Apr/Jun;33(2):67-72 Authors: Gómez Ochoa SA, Espín Chico BB Abstract Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported demographic, clinical, laboratory and imaging data from patients with HCB in whom a PET scan had been performed. Eleven patients were evaluated (women 82%, Asian origin 91%, mean age 71 years). The main findings were an increase in glucose metabolism at the contralateral motor cortex related to recent episodes of hemiballism-hemichorea in 2 patients, and an altered metabolism in the affected basal ganglia in all of them: decreased in 10 patients (91%) and increased in 1 (9%). However during the acute period the patients showed only an increased metabolism, or even no changes. Contrary to what has previously been suggested in a metabolic failure hypothesis, changes in glucose metabolism in the basal ganglia may not be a key factor in the pathogenesis of HCB, and may potentially be a direct result of histological changes such as cellular ischemia and gliosis related to HCB development. PMID: 29984683 [Pub...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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This study utilised 5-FU-treatment in a model of colitis-associated CRC to develop a pre-clinical setting of intestinal mucositis coincident with manifestation of CRC.Materials/methods: On day 0, female C57BL/6 mice (n = 10/group); (1) saline control, (2) AOM/DSS control, or (3) AOM/DSS + 5-FU were injected with saline or AOM (i.p; 7.4 mg/kg). Groups 2 and 3 underwent cycles of seven days 2%w/v DSS followed by 14 days plain water. After three cycles, 5-FU was administered weekly (i.p; 75 mg/kg) to group 3 for five weeks. Clinical indicators were measured daily and colonoscopy performed at...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research
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Source: Materials Today Communications - Category: Materials Science Source Type: research
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Source: Carbon - Category: Materials Science Source Type: research
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Source: Minerva Stomatologica - Category: Dentistry Tags: Minerva Stomatol Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
(Natural News) Scientists have finished their first 3D scan of an underwater volcano located 300 miles off the coast of Oregon with a base the size of Austin and a main magma reservoir approximately two-thirds of the length of Manhattan. Dubbed Axial Seamount, the “deep-sea magma monster” is the youngest in the Cobb-Eickelberg seamount chain, a 1,120-mile-long line...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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