Dextromethorphan/Quinidine for Pseudobulbar Affect Following Stroke: Safety and Effectiveness in the PRISM II Trial

Publication date: Available online 30 June 2018Source: PM&RAuthor(s): Richard D. Zorowitz, David N. Alexander, Andrea E. Formella, Fred Ledon, Charles Davis, Joao SiffertAbstractBackgroundDextromethorphan (DM)/quinidine (Q) was approved for pseudobulbar affect (PBA) treatment based upon efficacy and safety trials in patients with PBA secondary to amyotrophic lateral sclerosis or multiple sclerosis. The PRISM II trial evaluated DM/Q as PBA treatment in patients with stroke, dementia or traumatic brain injury.ObjectiveTo report results from the stroke cohort of PRISM II, including the Stroke Impact Scale (SIS).DesignOpen-label trial evaluating twice daily DM/Q over 90 daysStudy participantsAdults (n=113) with a clinical diagnosis of PBA secondary to stroke; stable psychiatric medications were allowed.MethodsPRISM II was an open-label, 12-week trial enrolling adults with PBA secondary to dementia, stroke (reported here), or TBI. All study participants received DM/Q 20/10 mg twice daily. Study visits occurred at baseline and at day 30 and day 90.Setting150 US centers.Main Outcome MeasurementsPrimary efficacy measure was change from baseline to day 90 in Center for Neurologic Study-Lability Scale (CNS-LS) scores. Secondary outcomes included PBA episodes (estimated over 7 days), Clinical and Patient/Caregiver Global Impression of Change (CGI-C and PGI-C), Quality of Life-Visual Analog Scale (QOL-VAS), SIS, Patient Health Questionnaire (PHQ-9), and Mini-Mental State Examination (MMS...
Source: PMandR - Category: Rehabilitation Source Type: research

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Publication date: Available online 20 July 2018Source: Alzheimer's &DementiaAuthor(s): Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M. VerfaillieAbstractTauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease amo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Zhang L, Wu Q, Zhang Q, Lu G, Yuan Y, Wang T PMID: 30021417 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
CONCLUSIONS: This prospective study confirms the predictive value of normal CTT and normal resting pressure, in the evolution towards spontaneous faecal continence. If CTT is abnormal, irrespective of the ARM, bowel management will be necessary to obtain pseudo-continence. In these cases, ARM is not a designated examination. PMID: 30024699 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Bayer announced Friday that it will no longer sell a controversial, permanent form of birth control that thousands of women say led to serious complications. Essure, a non-surgical sterilization device that is inserted into the fallopian tubes and prevents pregnancy by producing scar tissue that blocks sperm from fertilizing eggs, will no longer be available in the U.S. after December 31, 2018, Bayer announced in a statement. “This decision is based on a decline in U.S. sales of Essure in recent years and the conclusion that the Essure business is no longer sustainable,” the statement reads. While Bayer mainta...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime medicine onetime Source Type: news
Doctors say 3-year-old Molly McCabe saved her dad's life when he was having a stroke, by calling her mom, a nurse who was at work at the time
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
A barber from Belfast has travelled to a care home in Liverpool to offer haircuts to people with dementia.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Dr Mark Alberts discusses the benefits of using a CT profusion computer algorithm to identify patients with ischemic stroke who are candidates for thrombectomy.Medscape Neurology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Commentary Source Type: news
See something of interest? Please share our postings with colleagues in your institutions! Spotlight The MAReport: Check out the Spring 2018 issue of the MAReport newsletter! This quarter, Academic Coordinator Elaina Vitale talked about using evidence-based resources to improve citations on Wikipedia, and her experience with NNLM’s first virtual Wikipedia Edit-a-thon. National Network of Libraries of Medicine News Dementia and Alzheimer’s Services @ Your Library – Midwest Matters, from GMR The next round of PubMed for Librarians begins August 29. Register for any (or all) of the PML classes to learn ...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
Benefiber and Metamucil are two popular fiber supplements. Both products are designed to relieve constipation and promote gut health. Benefiber and Metamucil work in very similar ways but contain different types of fiber. Learn more about the similarities and differences between Benefiber and Metamucil here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Constipation Source Type: news
Conditions:   Sleep Disorder;   Complaint, Subjective Health Interventions:   Behavioral: Pittsburgh Sleep Quality Index;   Behavioral: Sleep diary;   Behavioral: Katz Index of Independence in Activities of Daily Living;   Behavioral: Lawton Instrumental Activities of Daily Living;   Behavioral: Neuropsychiatric Inventory (Cummings);   Behavioral: Mini Zarit Caregiver Burden Scale, for the caregiver;   Behavioral: Mini Mental state examination;   Behavioral: Cornell Scale for Depression in Demen...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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