Enantioconvergent Biocatalytic Redoxisomerization.

Enantioconvergent Biocatalytic Redoxisomerization.
Angew Chem Int Ed Engl. 2018 Jul 09;:
Authors: Liu YC, Merten C, Deska J
Abstract
Alcohol dehydrogenases can act as powerful catalysts in the preparation of optically pure γ-hydroxy-δ-lactones by means of an enantioconvergent dynamic redoxisomerization of readily available Achmatowicz-type pyranones. Imitating the traditionally metal-mediated borrowing hydrogen approach to shuffle hydrides across molecular architectures and interconvert functional groups, this chemoinspired and purely biocatalytic interpretation effectively expands the enzymatic toolbox and provides new opportunities in the assembly of multi-enzyme cascades and tailor-made cellular factories.
PMID: 29984878 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - July 9, 2018 Category: Chemistry Authors: Liu YC, Merten C, Deska J Tags: Angew Chem Int Ed Engl Source Type: research