Effectiveness and safety of anakinra in gout patients with stage 4–5 chronic kidney disease or kidney transplantation: A multicentre, retrospective study
ConclusionAnakinra may be a safe therapeutic option for gout patients with advanced CKD. Further randomized controlled studies are required to confirm our results.
Conclusion: Topical minoxidil is efficacious for the treatment of hair loss due to male and female androgenic alopecia, alopecia areata, with case-by-case application for traction alopecia, hair transplantation, and congenital hair disorders. Combination therapies using minoxidil with systemic, topical, and injectable therapies demonstrate increased effectiveness over monotherapies. J Drugs Dermatol. 2019;18(2):155-160. PMID: 30794366 [PubMed - as supplied by publisher]
Authors: Huang A, Fang G, Pang Y, Pang Z Abstract Longzuan Tongbi Formula (LZTB) is an effective proved prescription in Zhuang medicine for treating active rheumatoid arthritis (RA). However, its active ingredients, underlying targets, and pharmacological mechanism are still not clear in treating RA. We have applied network pharmacology to study LZTB and found that 8 herbs in LZTB and 67 compounds in the 8 herbs are involved in the regulation of RA-related genes; we have conducted pathway analysis of overlapping genes and found that 7 herbs participate in the regulations of 24 pathways associated with RA and that 5...
We present our experience with hypothermic machine perfusion (HMP) versus cold storage (CS) in relation to kidney transplant outcomes. Methods: Retrospective analysis of 33 consecutive HMP kidney transplant outcomes matched with those of 33 cold stored: delayed graft function (DGF), length of hospital stay (LOS), estimated glomerular filtration rate (eGFR), and patient and graft survival were compared. Renal Resistive Indexes (RIs) during HMP in relation to DGF were also analysed. Results: In the HMP group, mean HMP time was 5.7 ± 3.9 hours with a mean cold ischaemic time (CIT) of 15 ± 5.6 versus 15...
ARTHRITIS has no cure, but symptoms can be reduced with foods, supplements and medication containing anti-inflammatory properties. Here are five of the best supplements for joint pain.
ConclusionThis study highlights the ongoing risk of opportunistic infection several years after transplantation and adds weight to potential person to person Pneumocystis jirovecii transmission. Risk factors have been identified which may highlight those most at risk, allowing targeted rather than blanket long-term PCP prophylaxis.
ConclusionOur results demonstrated that Ha-EtOAc exhibited anti-inflammatory effects mainly by suppressing the NF-κB and MAPK pathways, and Ha-EtOAc treatment may be a potent therapy for the treatment of ulcerative colitis.Graphical abstract
Publication date: March 2019Source: Revista Española de Cardiología (English Edition), Volume 72, Issue 3Author(s): José Luis Martínez-Sande, Javier García-Seara, Laila González-Melchor, Moisés Rodríguez-Mañero, Inés Gómez-Otero, José Ramón González-Juanatey
In this study, we have developed four different quantitative structure and 5-LOX inhibition activity relationship models of benzoquinone derivative by exploiting CoMFA, RF, SVM, and MLR chemometric methods. Performance of the QSAR models was measured by using cross-validation technique as well as through the external test set prediction. RF model outperforms all other models. SVM and MLR models failed due to the poor performance of the external test set prediction. CoMFA model, which shows relatively good performance was used to explore the essential structural regions where the modification was necessary to design a novel...
When Carlos Acosta was able to fly his son out of a Venezuela that lacked basic medical supplies and see him receive a bone marrow transplant in Spain, it was as if his prayers had been answered
Conclusion Anakinra may be a safe therapeutic option for gout patients with advanced CKD. Further randomized controlled studies are required to confirm our results.