Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis

Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Kathryn C. Fitzgerald, Diane Vizthum, Bobbie Henry-Barron, Amy Schweitzer, Sandra D. Cassard, Eric Kossoff, Adam L. Hartman, Dimitrios Kapogiannis, Patrick Sullivan, David J. Baer, Mark P. Mattson, Lawrence J. Appel, Ellen M. MowryAbstractAn intermittent fasting or calorie restriction diet has favorable effects in the mouse forms of multiple sclerosis (MS) and may provide additional anti-inflammatory and neuroprotective advantages beyond benefits obtained from weight loss alone. We conducted a pilot randomized controlled feeding study in 36 people with MS to assess safety and feasibility of different types of calorie restriction (CR) diets and assess their effects on weight and patient reported outcomes in people with MS. Patients were randomized to receive 1 of 3 diets for 8 weeks: daily CR diet (22% daily reduction in energy needs), intermittent CR diet (75% reduction in energy needs, 2 days/week; 0% reduction, 5 days/week), or a weight-stable diet (0% reduction in energy needs, 7 days/week). Of the 36 patients enrolled, 31 (86%) completed the trial; no significant adverse events occurred. Participants randomized to CR diets lost a median 3.4 kg (interquartile range [IQR]: −2.4, −4.0). Changes in weight did not differ significantly by type of CR diet, although participants randomized to daily CR tended to have greater weight loss (daily CR: −3.6 kg [IQR: −3.0, −4.1...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research