Novel Insights on Understanding of Keloid Scar: Article Review

Publication date: December 2015Source: Journal of the American College of Clinical Wound Specialists, Volume 7, Issues 1–3Author(s): Walid Mari, Sami G. Alsabri, Najib Tabal, Sara Younes, Abdulamagid Sherif, Richard SimmanAbstractKeloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. In this review, PubMed, clinical key and Wright State Library web site have been used to investigate any update regarding Keloid disease. We used Keloid, scar formation, hypertrophic scar and collagen as key words. More than 40 articles have been reviewed. This paper reviews literature about keloid scar formation mechanism, the most recent therapeutic options including the ones under research.
Source: Journal of the American College of Clinical Wound Specialists - Category: General Medicine Source Type: research

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Condition:   Keloid Interventions:   Drug: Bleomycin;   Drug: Normal saline Sponsors:   Erasmus Medical Center;   Centre for Human Drug Research, Netherlands Not yet recruiting
Source: - Category: Research Source Type: clinical trials
We describe the varied uses of hyaluronidase in dermatology and the underlying evidence base for its dermatological indications. This includes its uses in enhancing drug delivery (for local anesthesia, keloid and hypertrophic scars, and for Kaposi’s sarcoma), in the treatment of disorders associated with mucin deposition (myxedema, scleroderma, scleredema, and cutis verticis gyrata) and its potential uses in surgery (as a pre-operative adjuvant in dermatofibrosarcoma protuberans, for periorbital edema, and for hematomas). In select circumstances, hyaluronidase might be more efficacious than more established treatment...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Mast cells (MCs) are an important immune cell type in the skin and play an active role during wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re-epithelialisation as well as angiogenesis, and promote skin scarring. There is also a link between MCs and abnormal pathological cutaneous scarring, with increased numbers of MCs found in hypertrophic scars and keloid disease. However, there has been conflicting data regarding the specific role of MCs in scar formation in both animal and human studies. Whilst animal studies have proved to be valuable in studying the MC phenomenon in wound healin...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
No abstract available
Source: Dermatologic Surgery - Category: Dermatology Tags: Letters and Communications Source Type: research
We report a 34-year-old woman with a medical history of asthma and Raynaud's phenomenon, presented for the evaluation and management of multiple erythematous hyperpigmented annular plaques reportedly developed after taking trimethoprim/sulfamethoxazole. An initial skin biopsy showed findings supportive of a drug eruption. She was treated with oral prednisone and achieved some improvement. She presented 1 year later with enlargement of the plaques and emergence of new lesions. Skin biopsies revealed an unremarkable epidermis with marked fibrosis of the mid-to-deep dermis with sparing of the papillary dermis, and superficial...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research
In conclusion, categorization of the stroma based on the amount of stroma and its infiltrating lymphocytes shows clinical relevance in early OTSCC superior to categorization based on the maturity of stroma.
Source: Virchows Archiv - Category: Pathology Source Type: research
Conclusion: The polymorphism of the NEDD4 gene rs8032158 could participate in the formation of keloids in the Egyptian population. The NEDD4 rs8032158 CC genotype may have a role in keloid severity. PMID: 32943899 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Hypertrophic scarring and keloid can cause significant emotional and physical discomfort. Cosmetic appearance, functional limitations, pain and pruritus form a degree of impairment. While the aetiology is not fully known, there is a wide array of treatment options which include excision, radiation, cryotherapy, silicone gel sheeting and intralesional injections. A relatively new modality is laser therapy. While results are promising, the number of different laser systems is substantial. This review evaluates the available evidence regarding outcomes on specific objective characteristics (i.e., erythema, pigmentation, heigh...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
Conditions:   Keloid;   Autologus Adipose Derived Stem Cells;   Feasibility;   Safety Intervention:   Biological: Autologous adipose derived stem cells Sponsor:   Makerere University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Keloid;   Autologus Adipose Derived Stem Cells;   Feasibility;   Safety Intervention:   Biological: Autologous adipose derived stem cells Sponsor:   Makerere University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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