Rapid response to an emerging infectious disease – Lessons learned from development of a synthetic DNA vaccine targeting Zika virus

Publication date: Available online 17 March 2018Source: Microbes and InfectionAuthor(s): Sagar B. Kudchodkar, Hyeree Choi, Emma L. Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N. Maslow, Charles C. Reed, Scott White, J. Joseph Kim, Gary P. Kobinger, Pablo Tebas, David B. Weiner, Kar MuthumaniAbstractVaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective new vaccines against infectious pathogens such as influenza, Human immunodeficiency virus (HIV), dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging. Zika virus is a mosquito-vectored flavivirus responsible for periodic outbreaks of disease in Africa, Southeast Asia, and the Pacific Islands dating back over 50 years. Over this period, ZIKV infections were subclinical in most infected individuals and resulted in mild cases of fever, arthralgia, and rash in others. Concerns about ZIKV changed over the past two years, however, as outbreaks in Brazil, Central American countries, and Caribbean islands revealed novel aspects of infection including vertical and sexual transmission modes. Cases have been reported showing dramatic neurological pathologies including microcephaly and other neurodevelopmental problems in babies born to ZIKV i...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research

Related Links:

Publication date: Available online 10 October 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Ícaro Boszczowski, Francisco Chiaravalloti Neto, Marta Blangiardo, Oswaldo Santos Baquero, Geraldine Madalosso, Denise Brandão de Assis, Thais Olitta, Anna S. Levin
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 10 October 2020Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Natália Freire Valente, Eliezer de Sousa Cardoso, Juliana Alencar da Silva Resende, Jeferson Antônio Santos
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
Publication date: Available online 10 October 2020Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Mateus Meira Vasconcelos, João Paulo Jordão Pontes, Alexandre de Menezes Rodrigues, Demócrito Ribeiro de Brito Neto, Rodrigo Rodrigues Alves, Fernando Cássio do Prado Silva, Denis Fabiano de Souza
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 10 October 2020Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Nilgun Kavrut Ozturk, Ali Sait Kavakli, Ulku Arslan, Guzin Aykal, Murat SavaƟ
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 9 October 2020Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Hande Gurbuz Aytuluk, Kemal Tolga Saracoglu
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 9 October 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Manuel Jorge Rial, Marcela Valverde, Victoria del Pozo, Francisco Javier González-Barcala, Carlos Martínez-Rivera, Xavier Muñoz, José María Olaguibel, Vicente Plaza, Elena Curto, Santiago Quirce, Pilar Barranco, Javier Domínguez-Ortega, Joaquin Mullol, César Picado, Antonio Valero, Irina Bobolea, Ebymar Arismendi, Paula Ribó, Joaquín Sastre
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 17 March 2018 Source:Microbes and Infection Author(s): Sagar B. Kudchodkar, Hyeree Choi, Emma L. Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N. Maslow, Charles C. Reed, Scott White, J. Joseph Kim, Gary P. Kobinger, Pablo Tebas, David B. Weiner, Kar Muthumani Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective vaccines against infectious path...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
With cases rising in Florida, Singapore, Vietnam and Trinidad and Tobago, the Zika virus pandemic is raising public concern in regions across the globe, including the U.S., where about 80 percent of Americans are aware of it but only 40 percent understand how it is actually transmitted. This raises a host of questions not only about the clinical and epidemiological scope of the outbreak, but also about the ability of citizens, public health authorities and politicians at all levels to adequately deal with it.  So far, the response has been slow and the challenge remains serious and unpredictable. We need to understand...
Source: Science - The Huffington Post - Category: Science Source Type: news
More News: African Health | Babies | Biology | Brain | Brazil Health | Chikungunya | Dengue Fever | Ebola | Ebola Vaccine | Emergency Medicine | Guillain-Barr Syndrome | Infectious Diseases | Influenza | Influenza Vaccine | International Medicine & Public Health | Lessons | Neurology | Outbreaks | Vaccines | Veterinary Vaccinations | WHO | Zika Virus