Treatment and outcome patterns in European patients with Waldenström's macroglobulinaemia: a large, observational, retrospective chart review

Publication date: July 2018Source: The Lancet Haematology, Volume 5, Issue 7Author(s): Christian Buske, Shalal Sadullah, Efstathios Kastritis, Alessandra Tedeschi, Ramón García-Sanz, Lukasz Bolkun, Xavier Leleu, Wolfgang Willenbacher, Roman Hájek, Monique C Minnema, Mei Cheng, Elizabeth Bilotti, Thorsten Graef, Meletios A Dimopoulos, European Consortium for Waldenström's MacroglobulinemiaSummaryBackgroundTreatment options for Waldenström's macroglobulinaemia are heterogeneous, and no well established treatment standards exist. Although guidelines from the Eighth International Workshop on Waldenstrom's Macroglobulinemia were published in 2016, inconsistent awareness and budget constraints have prevented their widespread implementation, and real-life treatment patterns might differ across health-care systems. We aimed to generate information about treatment and outcome patterns for patients with Waldenström's macroglobulinaemia outside of clinical trials.MethodsIn this large, observational, retrospective chart review, academic and community physicians in ten European countries were invited to retrospectively complete electronic records for patients with symptomatic Waldenström's macroglobulinaemia who had begun treatment after Jan 1, 2000, and before Jan 1, 2014, and had available clinical and biological data. The primary endpoints were reasons for treatment initiation, treatment choices, progression-free survival, and overall survival. We assessed the variables that aff...
Source: The Lancet Haematology - Category: Hematology Source Type: research