In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Publication date: Available online 25 February 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Alexandra Barbouti, Konstantinos Evangelou, Ioannis S. Pateras, Alexandra Papoudou-Bai, Amalia Patereli, Kalliopi Stefanaki, Dimitra Rontogianni, Daniel Muñoz-Espín, Panagiotis Kanavaros, Vassilis G. GorgoulisAbstractCellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor™, a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
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