Optimal HbA1c Cut-Off Point for Diagnosis of Type 2 Diabetes in Iranian Adults
Publication date: Available online 12 March 2018Source: Canadian Journal of DiabetesAuthor(s): Farideh Razi, Patricia Khashayar, Robabeh Ghodssi-Ghassemabadi, Mohsen Mehrabzadeh, Maryam Peymani, Fatemeh Bandarian, Ensieh Nasli EsfahaniAbstractObjectiveThe aim of this study was to evaluate the capability of HbA1c as a tool for identifying diabetic and prediabetic Iranian adults.MethodIn a cross-sectional population-based study, 1813 adults comprised of men and women aged 35-75 years without history of diabetes and hemoglobinopathies were included. Fasting blood glucose and HbA1c levels were obtained. According to ADA criteria, participants were categorized into three groups: newly diagnosed diabetes, prediabetic and healthy subjects. The optimal cut-off point for HbA1c in diabetes and prediabetes diagnosis was determined by studying the sensitivity and specificity of different cut-off points for HbA1c, while using different levels of fasting blood glucose as the gold standard.ResultsParticipants with newly diagnosed diabetes, were significantly older than prediabetic and healthy subjects (47.3±12.9, 44.6±13.0 and 39.2±14.1 yrs, respectively) and also had higher body mass index. As expected, the levels of fasting blood glucose (8.79±2.24, 6.01±0.38, and 4.97±0.4 mmol/L) and HbA1c (6.55±1.4, 5.61±0.61, 5.28±0.59) were significantly different between the groups (p
AbstractDespite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy balance of an organism depends on the equality between calorie intake within the system and energy expenditure, the regulation of energy content in biological systems oversteps the classical physical laws of thermodynamics. The fine-tuned mechanism for body weight and energy storage regulation is aimed ...
TYPE 2 diabetes does not pose a threat if you keep blood sugar levels under control. Diet acts as the ultimate bulwark against high blood sugar levels and a natural green powder has been proven to lower blood sugar.
Publication date: Available online 24 May 2020Source: Canadian Journal of DiabetesAuthor(s): Jacob M. Zamora, Jason M. Kong
Type 2 diabetes (T2D) shows a high mortality rate, dependent on disease duration, comorbidities and glucose control over time. Data on patients with short disease duration are scanty.
AbstractHeart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specific prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fibrosis, inflammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade inflammation have been proposed to participate in HFpEF development. Furthermore, several recent studies demonstrated the occurrence of generalized lymphatic dysfunction in experimental models of risk factors for HFpEF, including obe...
Menditto Alexandra Prados-Torres Antonio Gimeno-Miguel The World Health Organization considers the non-adherence to medication a significant issue with global impact, especially in chronic conditions such as type 2 diabetes. We aim to study antidiabetic treatment initiation, add-on, treatment switching, and medication persistence. We conducted an observational study on 4247 individuals initiating antidiabetic treatment between 2013 and 2014 in the EpiChron Cohort (Spain). We used Cox regression models to estimate the likelihood of non-persistence after a one-year follow-up, expressed as hazard ratios (HRs). Metform...
Conclusion: Significant changes in resistivity index and flow velocities were observed in the retrobulbar vessels, especially in ophthalmic artery in diabetics compared to controls. CDI with results of increased resistance or decreased flow could be useful to predict individuals at higher risk for developing severe DR.
Conclusion: An autoimmune etiology for the association of thyroid and type-1diabetes has been well established. This study shows that type-2 diabetic patients can have more severity in the clinical presentation of TED. Therefore, the presence of type-2 DM in patients with TED can be a predictive factor for onset, progression, and severity of disease. Hence, a high concern of interest among treating ophthalmologists and endocrinologists regarding this entity would help in early prediction and decreased morbidity among such patients.
Publication date: Available online 23 May 2020Source: Preventive MedicineAuthor(s): Soraya J. van Etten, Loes Crielaard, Mirthe Muilwijk, Irene van Valkengoed, Marieke B. Snijder, Karien Stronks, Mary Nicolaou
TYPE 2 DIABETES is one of the underlying health conditions that make somebody more vulnerable to the effects of coronavirus. Now diabetics may face self-isolation while others are allowed to move on with their lives.