Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus

Publication date: April 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 2Author(s): Paweł Jan Stanirowski, Dariusz Szukiewicz, Monika Pazura-Turowska, Włodzimierz Sawicki, Krzysztof CendrowskiAbstractGestational diabetes mellitus and pregestational diabetes mellitus constitute carbohydrate metabolism disorders, which, if not diagnosed and adequately treated, lead to serious and often life-threatening pregnancy complications. According to a recently formulated hypothesis, some diabetes-related complications, such as fetal macrosomia, may be the result of disturbances in the transplacental transport of nutrients—in particular, excessive maternal-fetal glucose transfer. Throughout pregnancy, glucose flux across the placenta is mediated by the group of facilitative glucose transporters (GLUT), the expression of which in different placental compartments is the precondition for effective glucose uptake from maternal blood and its subsequent transfer to the fetal circulation. In diabetes-complicated pregnancies, the location, expression and activity of glucose transporters are modified to an extent that results in alterations in the maternal-fetal glucose exchange, potentially leading to an excessive supply of energy substrates to the fetus. This paper reviews the literature on the expression and activity of glucose transporter proteins—GLUT-1, GLUT-3, GLUT-4, GLUT-8, GLUT-9 and GLUT-12—in the human placenta, with a special focus on diabetes-complicate...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Gestational diabetes mellitus (GDM) is the most common obstetric metabolic disorder. Long-term health consequences, including type 2 diabetes, metabolic syndrome, and cardiovascular disease, are common with GDM. Postpartum glucose screening is recommended for women with a prior GDM pregnancy. Rates of postpartum screening compliance remain low. Interventions ranging from appointment reminder systems to personalized chronic disease education are being used, emphasizing future chronic disease risk for patients with a history of GDM. With these practice changes, clinicians can more thoroughly engage in the early identificatio...
Source: Obstetrics and Gynecology Clinics - Category: OBGYN Authors: Source Type: research
Three complications of pregnancy —preeclampsia, gestational diabetes mellitus, and intrauterine growth restriction (IUGR)—are thought to share a common etiology, in which abnormal placental development and the resulting maternal inflammatory response play a key role.1 These 3 conditions, known as great obstetrical syndromes, ar e unfortunately quite common in pregnancy. However, the field of metabolomics has provided a rapid approach in identifying biomarkers predictive of their outcome.2,3
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Supplement Source Type: research
ConclusionsSmoking during pregnancy is associated with an increased risk for GDM. Offspring birthweight is lowest in women, who continue smoking after the first trimester. If pregnancy is complicated by GDM, offspring birthweight is not influenced by smoking.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The findings suggest that type 1 diabetes mellitus in the third trimester of pregnancy is associated with postural changes, a decrease in the active ankle range of motion and increase in the anteroposterior oscillation of the center of pressure, with negative repercussions for postural control.
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Source Type: research
ConclusionsSmoking during pregnancy is associated with an increased risk for GDM. Offspring birthweight is lowest in women, who continue smoking after the first trimester. If pregnancy is complicated by GDM, offspring birthweight is not influenced by smoking.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Clinical practice guidelines on diabetes mellitus and pregnancy: ΙI. Gestational diabetes mellitus. Hormones (Athens). 2020 May 25;: Authors: Anastasiou E, Farmakidis G, Gerede A, Goulis DG, Koukkou E, Kourtis A, Mamopoulos A, Papadimitriou K, Papadopoulos V, Stefos T Abstract Gestational diabetes mellitus (GDM) is the most common metabolic disease of pregnancy and is associated with several perinatal complications. GDM is defined as diabetes diagnosed in the second or third trimester of pregnancy that was not clearly overt diabetes prior to gestation. In Europe, in 2016, the prevalence of GDM was...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more a...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Parallel with the rise of type 2 diabetes (T2DM) in the western world, the prevalence of gestational diabetes mellitus (GDM) is increasing, occurring in 8 –26% of pregnancies [1,2]. While GDM may lead to complications related to macrosomia and increases the postpartum risk for T2DM, women with pregestational T2DM are at increased risk of congenital anomalies [1,3]. Therefore, timely detection of overt diabetes in pregnancy, GDM and postpartum glucos e intolerance is critical.
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Gestational diabetes mellitus (GDM) is associated with an increased risk for a future type 2 diabetes mellitus in women and their children. As linkage between maternal health and non-communicable diseases, ant...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Conclusion: Metrics derived from peripheral blood neutrophil, monocyte, and lymphocyte counts are thought to reflect systemic immune-inflammation. Elevated MLR and NLR may be unfavorable prognostic factors for clinical outcomes in patients with hyperglycemia during pregnancy. PMID: 32425090 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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