Cystic Fibrosis Related Diabetes Screening in Adults: a Gap Analysis & Evaluation of A1C Accuracy

Publication date: Available online 2 May 2018Source: Canadian Journal of DiabetesAuthor(s): Julie A. Gilmour, Jenna Sykes, Edward Etchells, Elizabeth TullisAbstractOBJECTIVEWe sought to identify the gap in Cystic Fibrosis Related Diabetes (CFRD) screening, using an Oral Glucose Tolerance Test (OGTT), within our tertiary care clinic. Our second aim was to identify the A1C threshold that optimizes sensitivity and specificity for predicting CFRD and Impaired Glucose Tolerance (IGT).RESEARCH DESIGN AND METHODSThis retrospective study used data housed within the Toronto Cystic Fibrosis (CF) database. The study population included all adult (>18 years) patients seen in the CF clinic between January 1st, 2008 and December 31st, 2015. Descriptive statistics were used for the OGTT gap analysis; the CFRD screening rate was calculated on an annual basis as the proportion of eligible patients who received an OGTT. Sensitivity and specificity were calculated using OGTT as the reference standard and A1C as the index test on a sample size of 320 patients.RESULTSOn average, 48.5% of eligible individuals were screened each year for CFRD with an OGTT. An A1C threshold of 5.5% had a sensitivity of 91.8% (75%) and a specificity of 34.1% (33.4%) for the diagnosis of CFRD (and IGT), respectively. Of the 229 patients with an A1C
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Condition:   Cystic Fibrosis-related Diabetes Interventions:   Drug: A-F-A-F (NovoRapid-FIASP-NovoRapid-FIASP);   Drug: F-A-F-A (FIASP-NovoRapid-FIASP-NovoRapid) Sponsor:   University Hospital, Strasbourg, France Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis-related Diabetes Intervention:   Behavioral: therapeutic optimization Sponsor:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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