Cystic Fibrosis Related Diabetes Screening in Adults: a Gap Analysis & Evaluation of A1C Accuracy
Publication date: Available online 2 May 2018Source: Canadian Journal of DiabetesAuthor(s): Julie A. Gilmour, Jenna Sykes, Edward Etchells, Elizabeth TullisAbstractOBJECTIVEWe sought to identify the gap in Cystic Fibrosis Related Diabetes (CFRD) screening, using an Oral Glucose Tolerance Test (OGTT), within our tertiary care clinic. Our second aim was to identify the A1C threshold that optimizes sensitivity and specificity for predicting CFRD and Impaired Glucose Tolerance (IGT).RESEARCH DESIGN AND METHODSThis retrospective study used data housed within the Toronto Cystic Fibrosis (CF) database. The study population included all adult (>18 years) patients seen in the CF clinic between January 1st, 2008 and December 31st, 2015. Descriptive statistics were used for the OGTT gap analysis; the CFRD screening rate was calculated on an annual basis as the proportion of eligible patients who received an OGTT. Sensitivity and specificity were calculated using OGTT as the reference standard and A1C as the index test on a sample size of 320 patients.RESULTSOn average, 48.5% of eligible individuals were screened each year for CFRD with an OGTT. An A1C threshold of 5.5% had a sensitivity of 91.8% (75%) and a specificity of 34.1% (33.4%) for the diagnosis of CFRD (and IGT), respectively. Of the 229 patients with an A1C
AbstractPurpose of ReviewSoy isoflavones are known to have beneficial effects on several aspects of gastrointestinal physiological functions (contractility or motility, secretion, morphology, and barrier function). In this review, we discuss the effects of soy isoflavones on the overall gut function and inflammation and assess how these effects might be implicated in the treatment of several gut-related diseases.Recent FindingsSoy isoflavones influence several key aspects of gastrointestinal health: improve basal intestinal secretion, alleviate inflammation, limit intestinal morphological damage, and improve epithelial bar...
Authors: Er B, Çelebioğlu E, Yalçin E, Doğru D, Erden Aki Ö, Uzun Ö, Akova M, Özçelik U, Kiper N, Emri S Abstract BACKGROUND/AIM: The patients with cystic fibrosis (CF) are living longer, but respiratory failure is still the most common cause of mortality. The aim of this study is to investigate factors associated with severe lung disease in a cohort of adult patients with CF. MATERIALS AND METHODS: Demographic data, clinical and laboratory findings of the patients aged 18 years and more were collected and the patients were grouped according to forced expiratory volume in 1...
Condition: Cystic Fibrosis-related Diabetes Interventions: Drug: A-F-A-F (NovoRapid-FIASP-NovoRapid-FIASP); Drug: F-A-F-A (FIASP-NovoRapid-FIASP-NovoRapid) Sponsor: University Hospital, Strasbourg, France Not yet recruiting
Condition: Cystic Fibrosis-related Diabetes Intervention: Behavioral: therapeutic optimization Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Not yet recruiting