Managing the Course of Kidney Disease in Adults With Type 2 Diabetes: From the Old to the New

Publication date: June 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 3Author(s): Ronald M. Goldenberg, Murray Berall, Christopher T.M. Chan, David Z.I. Cherney, Julie A. Lovshin, Philip A. McFarlane, Peter A. Senior, Subodh Verma, Jordan J. WeinsteinAbstractDiabetic kidney disease (DKD) is a group of chronic kidney diseases that is associated with significant cardiovascular as well as all-cause morbidity and mortality. Although DKD is often progressive in nature, its evolution can be modified by intensive management of glycemia and blood pressure and inhibition of the renin-angiotensin-aldosterone system. This review provides an overview of how multifactorial interventions can provide renal protection and includes a discussion of the nonglycemic effects of incretin-based diabetes therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors) and sodium-glucose cotransporter-2 inhibitors within the kidney in patients with type 2 diabetes.RésuméLa néphropathie diabétique (ND) est une forme de néphropathie de longue durée qui est associée à une morbidité et une mortalité cardiovasculaire significative et à une morbidité et une mortalité toutes causes confondues. Bien que la ND soit souvent de nature évolutive, la prise en charge intensive de la glycémie et de la pression artérielle et l'inhibition du système rénine-angiotensine-aldostérone peuvent modifier son évolution. Cette revue donne un aperçu sur la manière do...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research