Nasal polyposis pathophysiology: Endotype and phenotype open issues

ConclusionsCRSwNP comprises several inflammatory endotypes defined by different pathogenic mechanisms. These endotypes correlate with the disease's clinical manifestations and behavior. A thorough understanding of CRSwNP endotypes will enable targeted medical therapies and tailored follow-up protocols.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research

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CONCLUSIONS: The residual disease rate in patients treated surgically was higher than previously reported (43.2%). Incidence of recurrence in patients treated conservatively was low (4.4%). Areas of improvements have been identified in adherence to endoscopic follow-up, histopathological reporting, and potential overuse of radiological surveillance. See Video Abstract at http://links.lww.com/DCR/B47. MANEJO ACTUAL DE PÓLIPOS COLORRECTALES MALIGNOS A TRAVÉS DE UNA RED REGIONAL DE CÁNCER DEL REINO UNIDO ANTECEDENTES: La incidencia de pólipos colorrectales malignos ha aumentado secundariament...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
Conclusion In elderly patients of at least 75 years with NSTE-ACS, antiplatelet therapy is frequently discontinued prematurely, most often within 30 days. Main reasons for discontinuing are need for (N)OAC, undergoing CABG or type II ACS as final diagnosis and suffering from dyspnoea while on ticagrelor.
Source: Coronary Artery Disease - Category: Cardiology Tags: Adjunctive Pharmacology Source Type: research
Publication date: Available online 9 December 2019Source: Life SciencesAuthor(s): Liqun Shang, Li Wang, Xiaolan Shi, Ning Wang, Long Zhao, Jing Wang, Cuicui LiuAbstractAimsThe present study explored the function and regulatory mechanism of High mobility group box 1 (HMGB1) in asthma.Main methodsOVA (ovalbumin)-induced asthmatic mice model and LPS-treated cellular model were established in this study. Airway inflammation was measured through detecting the expression of IL-4, IL-5, IL-13 and Interferon-γ (IFN-γ) in serum and BALF (bronchoalveolar lavage fluid) by ELISA kits. Bioinformatics predictive analysis, Ch...
Source: Life Sciences - Category: Biology Source Type: research
In a joint statement, the editors of six major scientific journals have expressed concerns about the Environmental Protection Agency’s (EPA) proposed rule “Strengthening Transparency in Regulatory Science,” which would bar the use of scientific studies in crafting regulations unless the underlying data “are publicly available in a manner sufficient for independent validation.” In the statement released on November 26, 2019, the editors of Science, Nature, PLOS, Cell Press, the Proceedings of the National Academy of Sciences, and The Lancet wrote: “We urge the EPA to continue to adopt a...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
ConclusionLow-dose aspirin or other NSAID use was not associated with reduced prostate cancer risk, neither overall nor according to anthropometric measures, smoking, or alcohol use. The variation according to outcome characteristics warrants further investigation.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
(Natural News) Turmeric is an Indian spice used to give curry it’s distinct golden color. But beyond its culinary use, turmeric is considered one of the most widely used medicinal herbs on the planet. This is because turmeric contains a compound called curcumin, which is responsible for its health benefits. These benefits range from reducing inflammation...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
For some patients, combining aspirin and direct oral anticoagulant (DOAC) therapy may increase the rates of bleeding without protecting them from adverse thrombotic outcomes, a new study has found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Condition:   Colonic Polyp Interventions:   Procedure: EMR-P;   Procedure: CEMR Sponsor:   First Affiliated Hospital of Zhejiang University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Objective This update of a 2007 guideline from the American Academy of Otolaryngology—Head and Neck Surgery Foundation provides evidence-based recommendations to manage adult rhinosinusitis, defined as symptomatic inflammation of the paranasal sinuses and nasal cavity. Changes from the prior guideline include a consumer added to the update group, evidence from 42 new systematic reviews, enhanced information on patient education and counseling, a new algorithm to clarify action statement relationships, expanded opportunities for watchful waiting (without antibiotic therapy) as initial therapy of acute bacterial rhinos...
Source: Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Authors: Tags: Guideline Source Type: research
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