Hybrid of dehydroergosterol and nitrogenous alternariol derivative from the fungus Pestalotiopsis uvicola

Publication date: Available online 10 July 2018Source: SteroidsAuthor(s): Guo-Mei Hou, Xiu-Mei Xu, Qian Wang, Dan-Yi Li, Zhan-Lin LiAbstractA new hybrid of dehydroergosterol and nitrogenous alternariol derivative, pestauvicomorpholine A (1), and three alternariol analogues (2−4) including a new aminated one, pestauvicolactone A (2), were isolated from the fermentation product of the fungus Pestalotiopsis uvicola on rice media. Compounds 1 and 2 represent the first example of aza-alternariol and aza-alternariol-steroid derived from transamination followed by intermolecular hetero-Diels-Alder reaction.Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research