Estradiol mediates relaxation of porcine lower esophageal sphincter

Publication date: August 2018Source: Steroids, Volume 136Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che HuangAbstractMost pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isometric transducers. We investigated the mechanism of estradiol-induced relaxation of the porcine LES using tetraethylammonium, apamine, iberiotoxin, glibenclamide, KT5720, KT5823, NG-nitro-l-arginine, tetrodotoxin, and ω-conotoxin GVIA. Reverse transcription polymerase chain reaction (PCR) analysis and immunohistochemistry (IHC) were performed to determine the existence of the G protein-coupled estrogen receptor (GPER) in the porcine LES. In endothelin-1-precontracted porcine LES strips, estradiol caused marked relaxations in a concentration-dependent manner. The mechanism of estradiol-induced relaxation on the porcine LES was associated with the potassium channel. Reverse transcription PCR analysis and IHC revealed that GPER was expressed in the sling and clasp fibers of the porcine LES. This finding suggests that GPER mediates the relaxation of the por...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research

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Abstract AIM: To evaluate clinical comorbidities and steroid use as risk factors for central serous retinopathy (CSR). METHODS: Using national insurance databases, we conducted a case-control study of beneficiaries with an incident diagnosis of CSR between 2007 and 2015 (n=35 492) and randomly selected controls matched on age-based and sex-based propensity scores (n=1 77 460). RESULTS: The mean age (SD) of cases was 49.1 (12.2) years, and the majority (69.2%) were male. Cases were more likely to have received steroids in the past year (OR 1.14, 95% CI 1.09 to 1.19, p
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
This study is registered with ClinicalTrials.gov, number NCT02139813, and is now completed.FindingsFrom May 13, 2014, to March 2, 2016, of 261 patients screened for eligibility, 253 (97%) were randomly assigned to OAGB (n=129) or RYGB (n=124). Five patients did not undergo their assigned surgery, and after undergoing their surgery 14 were excluded from the per-protocol analysis (seven due to pregnancy, two deaths, one withdrawal, and four revisions from OAGB to RYGB) In the per-protocol population (n=117 OAGB, n=117 RYGB), mean age was 43·5 years (SD 10·8), mean BMI was 43·9 kg/m2 (SD 5·6), 176 ...
Source: The Lancet - Category: General Medicine Source Type: research
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Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Health Care Private Practice Schools Slider Speech-Language Pathology Dysphagia dyspnea muscle strength skilled nursing facility Swallowing Disorders Source Type: blogs
Conclusions:This pooled analysis of AE data from one Phase 2 and three Phase 3 completed eliglustat trials demonstrates long-term safety and tolerability of eliglustat in the treatment of adults with GD1.DisclosuresPeterschmitt: Sanofi Genzyme: Employment. Freisens: Sanofi Genzyme: Employment. Hou: Sanofi Genzyme: Employment. Underhill: Sanofi Genzyme: Employment. Foster: Sanofi Genzyme: Employment. Gaemers: Sanofi Genzyme: Employment.
Source: Blood - Category: Hematology Authors: Tags: 201. Granulocytes, Monocytes, and Macrophages: Poster III Source Type: research
Background: The cough reflex in childbearing women has been found to be more sensitive to chemical stimuli than that in other populations. However, the effect of age and sex on the cough reflex threshold (CRT) triggered by mechanical stimuli has not been studied.Aim: Our objective was to explore the association between age and sex, and CRT triggered by mechanical stimuli (air pulses) in childbearing women using a previously validated laryngopharyngeal endoscopic esthesiometer and laser rangefinder (LPEER).Methods: A cohort of 118 subjects, half of whom were female (49%), aged 19-95 years (a mean of 55.7 years), were prospe...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Emily Catterall, 24, from Preston, Lancashire, went from a slim size eight to a 14 in just a few months after she developed a severely swollen abdomen out of the blue. Her GP said it was acid reflux.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract Women often see their primary care physicians for common acute conditions during pregnancy. These conditions may be caused by pregnancy (obstetric problems) or worsened by pregnancy (obstetrically aggravated problems), or they may require special consideration during pregnancy because of maternal or fetal risks (nonobstetric problems). Primary care physicians should know the differential diagnosis for common conditions during pregnancy and recognize the important findings of obstetric and urgent nonobstetric problems. The family physician can evaluate and treat most nonobstetric problems, although obstetr...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
The MedCline sleep assist device from Amenity Health, a San Diego, CA firm, won European regulatory approval to be marketed as a medical device for preventing acid reflux. We at Medgadget tried the MedCline ourselves and wrote a comprehensive review ...
Source: Medgadget - Category: Medical Devices Authors: Tags: GI Medicine OTC Source Type: blogs
Publication date: August 2018 Source:Steroids, Volume 136 Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che Huang Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isometric ...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Because consumption of the L. reuteri yogurt made with the ATCC PTA 6475 and DSM 17938 strains work by raising levels of oxytocin (in addition to local probiotic benefits on reducing H. pylori and acid reflux, for example, unusual for its upper, not just lower, gastrointestinal benefits), there are people who probably should not consume the yogurt.. Oxytocin is a multi-faceted hormone whose levels decline as we age, much as does growth hormone and other hormones. But, among its many varied effects is the potential for causing uterine contraction. That is why oxytocin is administered to provoke delivery of a term infan...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle anti-aging healing oxytocin probiotic reuteri skin wrinkles Source Type: blogs
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