Evaluation of anti-ulcer and ulcerative colitis of Sonchus oleraceus L

Publication date: Available online 12 May 2018Source: Saudi Pharmaceutical JournalAuthor(s): Esraa A. Alothman, Amani S. Awaad, Amal A. Safhi, Shekhah S. Almoqren, Reham M. El-Meligy, Yara M. Zain, Fatmah A. Alasmary, Saleh I. AlqasoumiAbstractSonchus oleraceus L. was evaluated for its gastro antiulcerogenic and anti-ulcerative colitis activities Different extracts and fractions from Sonchus oleraceus aerial parts and roots were evaluated at different dose; total alcohol extracts of aerial parts SA and roots SR were evaluated doses 250 & 500 mg/kg, While Successive extracts (SAL, SRL, CSA, CSR, BSA & BSR) were evaluated at dose of 150 mg/kg. Absolute ethanol-induced ulcer model was used for evaluation of the anti-ulcerogenic activity. The root extract showed promising antiulcerogenic activity as the total alcohol extract of the root SR (500 mg/kg) produced 88.5% protection from control ulcer which is significantly more effective than the standard drug omeprazole (20 mg/kg), in addition, the butanol fraction of the root extract BSR also produced 76.66% protection from control ulcer. On the other hand, the aerial parts total extract SA showed low antiulcerogenic activity in both tested doses (250 & 500 mg/kg) as it produced 25% & 28.33% protection from control ulcer respectively. Only the butanol fraction of the aerial parts extract BSA showed promising activity 54.16%. In the acetic acid-induced ulcerative colitis model, among the investigated extracts of Sonchus ole...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research