Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs

ConclusionsAMK had significant toxic effects in rats with regard to decreased body weight, diminished renal and liver function, increased anemia and tumor incidence. Kidney, stomach, bladder and subcutaneous tissue are carcinogenic target organs of AMK or AAs, however liver is no- carcinogenic target organ of AMK or AAs in rats. AMK is carcinogenic in rats, and not be safe for humans.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research