Candida is a protractive factor of chronic oral ulcers among usual outpatients

Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin KasuyaSummaryAlthough many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associated with Candida among our frequent outpatients without an HIV infection. The present article reviews the causes of oral ulcers, focusing on Candida as a protractive factor for chronic oral ulcers, and it is recommended that Candida involvement be considered in diagnosis of a certain chronic oral ulcer, that remains of unknown origin even if some examinations have been performed.
Source: Japanese Dental Science Review - Category: Dentistry Source Type: research

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ConclusionsSH0.25% demonstrated potential for Candida spp. control in denture wearers with DS. The other protocols showed intermediate activity and might be more suitable for longer immersion periods.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Publication date: Available online 16 January 2020Source: Fungal BiologyAuthor(s): Alistair J.P. Brown, Daniel E. Larcombe, Arnab PradhanAbstractThe model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of stress cross-protection, whereby exposure to one type of stress can provide protection against subsequent exposure to a second type of stress. CERs have probably arisen through the accumulation, over evolutionary time, of protectiv...
Source: Fungal Biology - Category: Biology Source Type: research
Publication date: Available online 15 January 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Gopal Pandit, Karishma Biswas, Suvankar Ghosh, Swapna Debnath, Anil P. Bidkar, Priyadarshi Satpati, Anirban Bhunia, Sunanda ChatterjeeAbstractThe widespread abuse of antibiotics has led to the use of antimicrobial peptides (AMPs) as a replacement for the existing conventional therapeutic agents for combating microbial infections. The broad-spectrum activity and the resilient nature of AMPs has mainly aggrandized their utilization. Here, we report the design of non-toxic, non-hemolytic and salt tolerant und...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
In this study, we aim to explore the phenotyp...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a spectrum of inflammatory diseases. However, anakinra is rapidly cleared from the body and requires daily administration. To create a longer-lasting alternative, PASylated IL-1Ra (PAS–IL-1Ra) has been generated by in-frame fusion of a long, defined-length, N-terminal Pro/Ala/Ser (PAS) random-coil polypeptide with IL-1Ra. Here, we compared the efficacy of two PAS–IL-...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Immunology Source Type: research
ConclusionAlthough reflux was proposed to be associated with VP complications and pepsin was proven as a most sensitive and specific marker of EER, we did not find any statistically significant correlation between pepsin levels and occurrence of VP complications. A 3  months 40 mg pantoprazole therapy was ineffective in reduction of VP complications in our study group.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Candida auris has recently emerged as a global cause of multidrug resistant fungal outbreaks. An outbreak occurred at a tertiary care center in London in 2016. Transmission characteristics, interventions, patient outcomes and cost of resources are described.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Background: Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. Material and Methods: All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients’ demographic and clinical characteristics and causative Candida species were collected and analyzed. Regression analysis was used to identify factors independently associated with mortality. Results: One thousand three hundred ninety-five episodes of candidemia...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b20708
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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