Prevalence and short-term prognosis of heart failure: An in hospital prevalence study
ConclusionHeart failure occurs at a younger age in Indians compared to the western countries. The most common etiology is DCM followed by VHD. Since this is a retrospective analysis and has its own limitations, community based heart failure study taking a clue from the present study can be done to achieve invaluable data.
CONCLUSION: This study shows that participants with dyslexia fail to use normal brain regions specialized in language processing, but rather use different areas. PMID: 32086175 [PubMed - as supplied by publisher]
Authors: Liegeon G, Antoni G, Pialoux G, Capitant C, Cotte L, Charreau I, Tremblay C, Cua E, Senneville E, Raffi F, Meyer L, Molina JM, ANRS-IPERGAY study group Abstract INTRODUCTION: Daily pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is associated with a small but statistically significant decrease in estimated glomerular filtration rate (eGFR). We assessed the renal safety of on-demand PrEP with TDF/FTC in HIV-1 uninfected men. METHODS: We used data from the randomized double-blind placebo-controlled ANRS-IPERGAY trial and its open-label extension conducted betwee...
Publication date: Available online 22 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Anita A. Pinar, Tara E. Scott, Brooke M. Huuskes, Felipe E. Tapia Cáceres, Barbara K. Kemp-Harper, Chrishan S. SamuelAbstractCardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood vessels from an aberrant wound healing response to organ injury or insult. Established fibrosis becomes a hallmark of chronic disease progression and a key contributor to tissue stiffness and dysfunction, which ultimately leads to heart failure. As wound healing and fibrotic responses to myocardial inj...
CONCLUSIONS: These features resulted from a combination of the properties of cytoskeleton filaments and their temporary cross-linker. Our results substantiate that cross-linked filaments contribute, for the most part, to the mechanical strength of the cytoskeleton of the cell studied and the relaxation time is determined by the dissociation dynamics of the cross-linking proteins. The severity of biomechanical defects due to these LMNA mutations correlated with the severity of the clinical phenotype. PMID: 32083564 [PubMed - as supplied by publisher]
Authors: Ohba Y, MacVicar T, Langer T Abstract Mitochondria are multifaceted metabolic organelles and adapt dynamically to various developmental transitions and environmental challenges. The metabolic flexibility of mitochondria is provided by alterations in the mitochondrial proteome and is tightly coupled to changes in the shape of mitochondria. Mitochondrial proteases are emerging as important post-translational regulators of mitochondrial plasticity. The i-AAA protease YME1L, an ATP-dependent proteolytic complex in the mitochondrial inner membrane, coordinates mitochondrial biogenesis and dynamics with the meta...
Discussion and conclusion: The developed combination was found to be effective in nephrotoxicity; it can be explored further for the management of drug-induced nephrotoxicity and other chronic kidney diseases. PMID: 32083987 [PubMed - as supplied by publisher]
A Singapore tribunal in 2016 awarded Daiichi Rs 3,500 crore in damages. In May that year, the company moved Delhi High Court to enforce the award. The Singhs appealed against it in Singapore as well as India.
ConclusionsA DPM may result in faster access to CHF gene therapy and may thus reduce hospital admissions and mortality in contrast to a status quo payment with the same budget constraint. Although the financial benefits of a DPM in CHF gene therapy are limited, it is possible that deferred payments will show greater promise for treatments with higher cost offsets.
Conclusion Heart failure occurs at a younger age in Indians compared to the western countries. The most common etiology is DCM followed by VHD. Since this is a retrospective analysis and has its own limitations, community based heart failure study taking a clue from the present study can be done to achieve invaluable data.