Mitophagy induced by endoplasmic reticulum stress in heart is modulated by the sirtuin 1

ConclusionOur results show that activation of Sirt1 promotes the induction of mitophagy in response to ER stress, protecting the cardiac cells from cell death. Sirt1 thus appears as an interesting therapeutic target to modulate adaptive autophagy in ER stress-associated cardiac pathologies.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research