Connexin-43 expression is increased by the nerve growth factor (NGF) and contributes to pulmonary arterial altered reactivity in pulmonary hypertension

ConclusionsOur results show that NGF increases Cx43 expression in PA through activation of its TrkA receptor and a PI3K/ERK-dependent signalling pathway. This mechanism seems to participate in NGF-induced PA hyperreactivity and may thus contribute to PH pathophysiology.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research