LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Plasma cells secrete antibodies and play a key role in host defense against infection. Lino et  al. identify a novel subset of natural regulatory plasma cells characterized by the expression of LAG-3 that develops at steady state independently of microbiota, and respond to innate stimulation by producing immunosuppressive IL-10.

Source: Immunity - July 10, 2018 Category: Allergy & Immunology Authors: Andreia C. Lino, Van Duc Dang, Vicky Lampropoulou, Anna Welle, Jara Joedicke, Jelka Pohar, Quentin Simon, Jessie Thalmensi, Aurelia Baures, Vinciane Fl ühler, Imme Sakwa, Ulrik Stervbo, Stefanie Ries, Luc Jouneau, Pierre Boudinot, Takeshi Tsubata, Takahi Tags: Article Source Type: research