Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study

Publication date: July 2018Source: The Lancet Psychiatry, Volume 5, Issue 7Author(s): Line Olsen, Thomas Sparsø, Shantel M Weinsheimer, Marcelo Bertalan Quintanilha Dos Santos, Wiktor Mazin, Anders Rosengren, Xabier Calle Sanchez, Louise K Hoeffding, Henriette Schmock, Marie Baekvad-Hansen, Jonas Bybjerg-Grauholm, Mark J Daly, Benjamin M Neale, Marianne G Pedersen, Esben Agerbo, Ole Mors, Anders Børglum, Merete Nordentoft, David M Hougaard, Preben Bo MortensenSummaryBackgroundAlthough the pathogenic nature of copy number variants (CNVs) on chromosome 22q11.2 has been recognised for decades, unbiased estimates of their population prevalence, mortality, disease risks, and diagnostic trajectories are absent. We aimed to provide the true population prevalence of 22q11.2 CNVs and associated trajectory of disease risk and mortality by use of the unbiased, representative Danish iPSYCH population case cohort.MethodsThis case-cohort study was done on a population of 86 189 individuals selected from the iPSYCH case cohort of 1 472 762 singletons born in Denmark between May 1, 1981, and Dec 31, 2005, who have a known mother from the Danish Civil Registration System, were residents in Denmark at 1 year of age, and enrolled in the iPSYCH Initiative. We used epidemiological methods in conjunction with nationwide hospital registers to analyse the iPSYCH case cohort of individuals with attention-deficit hyperactivity disorder (ADHD), major depressive disorder, schizophren...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research

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Authors: Wietersheim JV, Knoblauch JD, Rottler E, Weiß H, Hartmann A, Rochlitz P, Völker A, Scheidt CE, Beutel ME, Eckhardt-Henn A, Zeeck A Abstract Several therapeutic treatments like individual psychotherapy, group therapy, creative therapies and talks with the nursing staff are components in an inpatient psychosomatic (psychotherapeutic) treatment or a psychosomatic day hospital treatment. In Germany, these therapies have to be documented by the administration with so called OPS-Codes. These codes are reported to the Institute for Reimbursement in Hospitals (InEK). With the data of the INDDEP-study it...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Authors: Priegnitz J, Langheim E, Rademacher W, Schmitz C, Köllner V Abstract An integrative patient-centered care concept is increasingly demanded for treatment of cardiac patients with concomitant mental disorders. The present study aims to investigate the effect of an integrated concept of psycho-cardiac care (PK) versus a monodisciplinary cardiac (K) or psychosomatic (PSO) care. Patients were examined at baseline (T0), at the time of discharge from the rehabilitation program (T1) and after 6 month (T2). General anxiety, depression (HADS), cardiac anxiety (HAF) and quality of life (SF-12) were evaluated usi...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Conclusions: Findings suggests that dual users of alcohol and marijuana with negative affect symptoms engage in substance use for similar reasons as single substance users with negative affect symptoms. Intervention efforts should examine ways to replace substance-related coping and expansion methods with non-substance-related methods. PMID: 31818171 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Publication date: March 2020Source: Biomedical Signal Processing and Control, Volume 57Author(s): Susanta Kumar Rout, Pradyut Kumar BiswalAbstractIn this paper, variational mode decomposition (VMD), Hilbert transform (HT), and proposed error-minimized random vector functional link network (EMRVFLN) are integrated to detect and classify epileptic seizure from electroencephalogram (EEG) signals. VMD is applied to decompose the EEG signal into Band-limited intrinsic mode functions (BLIMFs). The five efficacious instantaneous features are computed using HT to construct the feature vector. Proposed EMRVFLN classifier is used to...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Authors: Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T Abstract To review the outcome of vagus nerve stimulation (VNS) therapy in all implanted Slovenian patients with drug-resistant epilepsy, data on 48 patients implanted between 2001 and 2015 were obtained retrospectively from medical records. The outcome was assessed in 2016. Out of 48 patients, 39 responded at follow up. The seizure frequency was reduced in 18 (46.2%) patients; 13 (33.3%) of them reported ≥50% reduction after 12 months of therapy. The responder rate was higher among patients implanted before the age of six years. Ictal severity de...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Authors: Singh AK, Singh R Abstract BACKGROUND: Lorcaserin is a novel, selective 5-hydroxytryptamine 2C serotonin receptor agonist, approved for the treatment of obesity. Several phase 3 randomized controlled trials (RCTs) trials have shown a significant reduction in body weight with lorcaserin. RESEARCH DESIGN AND METHODS: We systematically searched the database of PubMed, Embase, The Cochrane Library and ClinicalTrials.gov up to July 31, 2019 and retrieved all the studies conducted with lorcaserin for ≥ 1-year that have explicitly reported the efficacy and safety outcomes versus placebo. Subsequently, we s...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Marinus Pharmaceuticals Inc. expects to bring in $65 million this week from a public stock offering and concurrent private placement. The proceeds from the stock sales will be used by the Radnor company to advance the preclinical and clinical development of ganaxolone, its lead new drug candidate. Marinus is developing ganaxolone as a potential treatment for epilepsy, depression and other neuropsychiatric disorders. The funds wi ll be used for clinical trial expenses related to the company's seizure…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Chairman of The Nippon Foundation Yohei Sasakawa and BRAC Executive Director Asif Saleh announcing $2 million partnership. Credit: Rafiqul Islam / IPSBy Rafiqul IslamDHAKA, Bangladesh, Dec 11 2019 (IPS) In the light of limited access to education for displaced Rohingya children, the Nippon Foundation has announced US$ 2 million support to BRAC to launch a project to ensure educational facilities to both Rohingya and local community children. The Nippon Foundation made the announcement at a press conference at the BRAC Centre in Dhaka, which was attended by Nippon Foundation chairman Yohei Sasakawa and BRAC Executive Direc...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Conferences Development & Aid Education Featured Headlines Health Human Rights Migration & Refugees Poverty & SDGs TerraViva United Nations National Leprosy Conference - Dhaka 2019 Source Type: news
Conditions:   Back Pain;   Back Pain With Radiation Interventions:   Diagnostic Test: Pressure pain assessment using computer controlled cuff algometry;   Diagnostic Test: Temporal summation (TS);   Diagnostic Test: Conditioned pain modulation (CPM);   Diagnostic Test: Low back pain rating scale (LBPRS-pain);   Diagnostic Test: Oswestry Disability Ind ex Sponsor:   Spine Centre of Southern Denmark Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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