Comparative analysis of a fully-synthetic nanofabricated dura substitute and bovine collagen dura substitute in a large animal model of dural repair

ConclusionsSynthetic nanofabricated dural substitute and bovine collagen dural substitute demonstrated effective repair of induced dural defects and successfully prevented CSF leakage without infection or damage to underlying brain tissue. Nanofabricated dura substitute exhibited increased neoduralization, reduced cortical adhesions, and progressive resorption compared to the bovine collagen membrane. Fully-synthetic nanofabricated dura substitute further demonstrated less inflammation, irritation, and fibrosis than the bovine collagen material. Nanofabricated dura substitute thereby provides a unique non-biologic option in dural repair procedures, and offer reduced risk of inflammation and adhesions commonly associated with traditional xenogenic collagen products.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research