Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke

Publication date: March 2018Source: Neurologia i Neurochirurgia Polska, Volume 52, Issue 2Author(s): Wojciech Ambrosius, Justyna Rosinska, Slawomir Michalak, Maria Lukasik, Radoslaw Kazmierski, Wojciech KozubskiAbstractThe role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) – one of the extracellular matrix molecules.In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43 ng/mL (p < 0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p = 0.03). In stroke patients, TSH concentration was lower than in the control group (p = 0.03). SC1 levels positively correlated with fT4 levels (p = 0.02) and negatively with TSH (p = 0.03) in stroke patients.Our results confirmed the association between thyroid hormones and SC1 – extracellular matrix protein.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research