Identification of Lyme borreliae proteins promoting vertebrate host blood-specific spirochete survival in Ixodes scapularis nymphs using artificial feeding chambers

In this study, we used this chamber model and showed that I. scapularis ticks will not only acquire bovine blood but human and quail blood as well. The latter two are the incidental host and an avian host of Lyme borreliae, respectively. We also investigated the roles that BBA52 and Lp6.6 play in promoting spirochete survival in nymphal ticks fed on human or quail blood. After feeding on human blood, spirochete burdens in ticks infected with an lp6.6-deficient B. burgdorferi were significantly reduced, while bba52-deficient spirochete burdens in ticks remained unchanged, similar to the wild-type strain. No strain showed a change in spirochete burdens in ticks fed on quail blood. These results indicate that Lp6.6 plays a role for B. burgdorferi in nymphs fed on human but not quail blood. Such information also demonstrates that the artificial feeding chamber is a powerful tool to identify B. burgdorferi proteins that promote vertebrate host blood-specific spirochete survival in I. scapularis ticks.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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The U.S. Food and Drug Administration said on Thursday two of the 16 currently used main chemical ingredients in over-the-counter sunscreen products are considered safe, as part of a proposal https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm631736.htm aimed at improving the safety and quality of sunscreen products sold without prescription in the United States.
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Source: Canadian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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