CXCL13 concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other neurological disorders determined by Luminex and ELISA

Publication date: July 2018Source: Ticks and Tick-borne Diseases, Volume 9, Issue 5Author(s): Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold StanekAbstractThe aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) – 25 samples per group – were analyzed. The performance of the Luminex recomBead CXCL13 assay (Microgen, Neuried, Germany) and ELISA (Euroimmun, Lübeck, Germany) was assessed by receiver operating characteristics. CXCL13 cut-off values were presented as functions of CSF lymphocyte/monocyte counts. Demographic variables, CSF findings, and history of erythema migrans were assessed as possible predictors for CXCL13 CSF concentrations by a general linear model. The calculated cut-off values determined by the maximum of the Youden index were>131 pg/mL for recomBead and>259 pg/mL for the ELISA. RecomBead showed a sensitivity of 88% (68.8–97.5%) and a specificity of 94% (83.5–98.7%). For the ELISA the corresponding values were 84% (63.9–95.5...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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yai K Abstract SUMMARYThe tick-borne pathogen Powassan virus is a rare cause of encephalitis in North America and the Russian Far East. The number of documented cases described since the discovery of Powassan virus in 1958 may be 50% of survivors make Powassan virus a medical concern requiring the attention of public health authorities and clinicians. The medical importance of Powassan virus justifies more research on developing specific and effective treatments and prevention and control measures. PMID: 30541872 [PubMed - in process]
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Publication date: December 2018Source: Sports Orthopaedics and Traumatology, Volume 34, Issue 4Author(s):
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Publication date: 15 April 2019Source: Personality and Individual Differences, Volume 141Author(s): Sonja Heintz, Willibald RuchAbstractInvestigating individual differences in humor has become a popular topic for personality research. Three approaches to humor-related styles were proposed in the literature, namely Craik, Lampert, and Nelson's (1996) five bipolar styles of humorous conduct, Martin, Puhlik-Doris, Larsen, Gray, and Weir's (2003) four humor styles, and Ruch, Heintz, Platt, Wagner, and Proyer (2018) eight comic styles. The present study aims to determine how many styles can be empirically distinguished by compa...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Publication date: April 2019Source: Learning and Instruction, Volume 60Author(s): Francesca Muntoni, Jan RetelsdorfAbstractFollowing expectancy-value theory, we investigated the role parents' reading-related gender stereotypes favoring girls play in explaining students' reading-related competence beliefs, intrinsic task values, and achievement. Drawing on a sample of 1508 students (49% girls, age at T1: 10.89 years) from 60 schools in Germany, we collected data at the beginning of Grade 5 and in the second half of Grade 6 using parent and student questionnaires. Structural equation modeling yielded two main results: First,...
Source: Learning and Instruction - Category: Psychiatry & Psychology Source Type: research
Publication date: January 2019Source: The Lancet Neurology, Volume 18, Issue 1Author(s): Diego Sepulveda-Falla, Andres Villegas, Francisco Lopera, Markus Glatzel
Source: The Lancet Neurology - Category: Neurology Source Type: research
Abiomed and Shockwave Medical just got a little bit closer. Recently the two companies announced that Danvers, MA-based Abiomed and one of the MDDI 2017 company finalists would be investing about $15 million in Shockwave. In addition, the two firms would be working on a training and education program in the U.S. and Germany focused on the benefits of complementary use of their respective technologies. Fremont, CA-based Shockwave has developed an intravascular lithotripsy technology that employs sonic pressure waves to safely crack vascular calcium within the vessel wall, which enables arteries to expand under low pressure...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Cardiovascular Source Type: news
Publication date: Available online 13 December 2018Source: The Lancet HIVAuthor(s): Joseph J Eron, Jean-Daniel Lelievre, Robert Kalayjian, Jihad Slim, Anson K Wurapa, Jeffrey L Stephens, Cheryl McDonald, Eric Cua, Aimee Wilkin, Brigitte Schmied, Mehri McKellar, Stephanie Cox, Sophia R Majeed, Shuping Jiang, Andrew Cheng, Moupali Das, Devi SenGuptaSummaryBackgroundCurrent treatment for HIV-infected individuals with renal failure on haemodialysis frequently requires complex regimens with multiple pills. A daily single-tablet regimen of coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide is approve...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Source: Journal of Hepatology - Category: Gastroenterology Source Type: research
A woman with rapidly worsening neuropsychiatric symptoms? Keep ovarian dermoid tumor on your radar.Medscape Ob/Gyn
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Commentary Source Type: news
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